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A potent inhibitor of purine nucleoside phosphorylase

8-Aminoguanosinea guanosine derivativeis an orally available and highly efficacious potassium-sparing diuretic/natriuretic th at increased sodium excretion by 26.2-fold and decrease potassium excretion by 69.1%. 8-Aminoguanosine increases glucose excretion by 12.2-fold. Also 8-Aminoguanosine suppressed deoxycorticosterone/salt-induced hypertension.''8-Aminoguanosine is known to stimulate diuresisnatriuresisglucosuria and antikaliuresis. It is an analog of guanosineth at can block purine nucleoside phosphorylasein vitro and in intact lymphoid cells. 8-aminoguanosine triphosphate can be used to block GTP (guanosine triphosphate) cyclohydrolase I from human liver and Escherichia coli.