105-41-9

1,3-dimethylamylamine or methylexaneamine (DMAA) is a synthetic pharmaceutical patented in the 1940s as a nasal decongestant which can be used as a recreational stimulant. Alleged to occur in nature，DMAA has become a widely used ingredient in sports food supplements, despite its status as a doping agent and concerns over its safety. The most popular brands containing DMAA include Jack3d? and OxyElite Pro?, both marketed by USP Labs and both detained by the FDA in July 2013 (however, some can still be found on Amazon and other online retail stores).

White or almost white powder

Forthane,Lilly,US,1948

1,3-Dimethylpentylamine is useful in compositions, for example as dietary supplements, and for appetite suppression.

Methylhexaneamine is a botanical ingredient in dietary supplements. Methylhexaneamine and caffeine has been combined in attempts to improve exercise performance and related variables.

1,3-Dimethylamylamine (1,3-DMAA) is a neural stimulant with a structure similar to ephedrine and adrenaline that has been used as a pre-workout stimulant. It is useful in compositions, for example as dietary supplements, and for appetite suppression. Methylhexaneamine is a botanical ingredient in dietary supplements. Methylhexaneamine and caffeine has been combined in attempts to improve exercise performance and related variables.

ChEBI: Methylhexaneamine is an alkylamine.

One molecular equivalent of 4-methylhexanone-2 is reacted with slightly more than one molecular equivalent of hydroxylamine. Desirably, the hydroxylamine is prepared in the presence of the 4-methylhexanone-2 by reacting the hydrochloride or sulfate or other salt of the hydroxylamine with a suitable base, such as sodium carbonate or sodium hydroxide. Desirably, the reaction mixture is agitated for a few hours to insure the conversion of the 4- methylhexanone-2 to 4-methylhexanone-2 oxime.
The resulting 4-methylhexanone-2 oxime separates and is dried by any suitable means, such as with a dehydrating agent, for example, sodium sulfate or magnesium sulfate. After drying, 4-methylhexanone-2 oxime is reduced with hydrogen by means of a catalyst, such as Raney nickel, or by reaction of sodium and a primary alcohol, such as ethanol. The resulting 2- amino-4-methylhexane may be purified by distillation, as described in US Patent 2,350,318.
115 g (1 mol) of 2-amino-4-methylhexane and 9 g (0.5 mol) of water are placed in a tared 500 cc 3-necked flask which is equipped with a mechanical stirrer, a thermometer, and a gas delivery tube. The flask is surrounded by a cooling bath of ice and water. Dry carbon dioxide gas is introduced into the solution through the gas delivery tube, with constant stirring, until the increase in weight is approximately 22 g (0.5 mol). The temperature during this addition is maintained between 20° and 30°C. A viscous liquid results, and consists essentially of 2-amino-4-methylhexane carbonate. This also dissociates very slowly at room temperature to the free amine, carbon dioxide, and water; and is effective as an inhalant, according to US Patent 2,386,273.

Nasal decongestant

Oral Clearance (CL) values (CL/F; F represents oral bioavailability) were found to be relatively low (20±5.0 L/hr), whereas oral Volume of distribution (V/F) was relatively high (236±38.0 L). A 25 mg single oral dose resulted in a maximum plasma concentration (Cmax) of 76.5 ng/mL, which occurred approximately 4 hours post-ingestion. Cmaxvalues were approximately 15-30 times lower than those reported in case studies linking 1,3-Dimethylamylamine (DMAA) intake with severe adverse events, suggesting that the reported adverse events were associated with a DMAA intake much higher than the 25 mg dose in our study [9,10]. Additionally, the potential impact of drug-drug interactions should be considered when interpreting DMAA adverse event reports. Because DMAA PK data suggest that a significant fraction of an orally administered DMAA dose is metabolized, concomitant administration of common ingredients that are also metabolized (e.g., caffeine), may lead to exaggerated DMAA concentrations by inhibiting DMAA clearance.

Taking 1,3-Dimethylamylamine (DMAA) can raise blood pressure and lead to cardiovascular problems ranging from shortness of breath and tightening in the chest to heart attack. It  may also cause stroke, a condition called lactic acidosis, heart attack, liver injury, and death.