100481-09-2

Yellow Oil

2-Thiazolesulfonyl chloride is used for preparation of substituted thiazolesulfonamides as antiglaucoma agents.

To a suspension of 2-mercaptothiazole (0.16 g, 1.37 mmol) in CH2Cl2 (14 mL) was added water (7 mL) followed by N-chlorosuccinimide (0.75 g, 5.6 mmol). The reaction mixture was stirred vigorously for 1.5 h. The reaction mixture was diluted with CH2Cl2, was