Trelagliptin

$49 - $1208.7

Product nameTrelagliptin
Cas No865759-25-7
MFC18H20FN5O2
MW357.38
EINECS1592732-453-0
MDL NumberMFCD22572746

Synonyms

Trelagliptin(syr472);Benzonitrile, 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H) -pyrimidinyl]methyl]-4-fluoro-;Trelagliptin (R)-2-[[6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]methyl]-4-fluorobenzonitrile;(S)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile;Trelagliptin Isomer Impurity;Trelagliptin, >=98%;Trelagliptin free base;Trelagliptin

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Price

30 prices

Brand less more

Cayman Chemical Crysdot TRC Biorbyt Ltd ApexBio Technology AK Scientific Ark Pharm ChemScene DC Chemicals
Package less more

10mm(in1mldmso) 1mg 2.5mg 5mg 10mg 25mg 50mg 100mg 250mg 1000mg

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Brand	Packaging	Price	Product name
AK Scientific 2763AH	10mg	$166	Trelagliptin
ApexBio Technology A3888	5mg	$80	Trelagliptin
ApexBio Technology A3888	10mg	$88	Trelagliptin
ApexBio Technology A3888	5mg	$55	Trelagliptin
ApexBio Technology A3888	10mM(in1mLDMSO)	$61	Trelagliptin
Ark Pharm P000057192	1mg	$52	Trelagliptin
Ark Pharm P000057192	5mg	$85	Trelagliptin
Ark Pharm P000057192	10mg	$137	Trelagliptin
Ark Pharm P000057192	50mg	$550	Trelagliptin
Biorbyt Ltd orb181339	250mg	$615.4	Trelagliptin

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Properties

Boiling point	519.0±60.0 °C(Predicted)
Density	1.38±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	≥11.6 mg/mL in DMSO; ≥3.68 mg/mL in EtOH with gentle warming and ultrasonic; ≥93.8 mg/mL in H2O
form	solid
pka	9.88±0.20(Predicted)
color	White to off-white
InChI	InChI=1S/C18H20FN5O2/c1-22-17(25)8-16(23-6-2-3-15(21)11-23)24(18(22)26)10-13-7-14(19)5-4-12(13)9-20/h4-5,7-8,15H,2-3,6,10-11,21H2,1H3/t15-/m1/s1
InChIKey	IWYJYHUNXVAVAA-OAHLLOKOSA-N
SMILES	C(#N)C1=CC=C(F)C=C1CN1C(=O)N(C)C(=O)C=C1N1CCC[C@@H](N)C1

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H302：Harmful if swallowed

H315：Causes skin irritation

H319：Causes serious eye irritation

H335：May cause respiratory irritation

Precautionary statements

P261：Avoid breathing dust/fume/gas/mist/vapours/spray.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312：IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Dipeptidyl peptidase 4 (DPP-4) is an intrinsic membrane glycoprotein that acts as an exopeptidase, cleaving oligopeptides after the second amino acid from the N-terminal end. One of its substrates is glucagon-like peptide 1, an incretin that stimulates insulin biosynthesis and secretion while inhibiting glucagon release in a glucose-dependent manner. Trelagliptin is a pyrimidinedione-based, long-acting inhibitor of DPP-4 (IC50 = 4 nM). It demonstrates >10,000-fold selectivity over other peptidases. Trelagliptin has been used to improve glucose tolerance and postprandial plasma insulin levels in Zucker fa/fa rats. In 2014 this compound underwent phase III clinical trials.

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Suppliers and manufacturers

Henan Bao Enluo International TradeCo.，LTD

$150.00/1kg

Trelagliptin

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Zibo Hangyu Biotechnology Development Co., Ltd

$65.00/1kg

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career henan chemical co

$2.00/1kg

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Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd.
Capot Chemical Co.,Ltd.
Shanghai Yingrui Biopharma Co., Ltd.
ATK CHEMICAL COMPANY LIMITED
Lianyungang happen teng technology co., LTD
Jinan Jianfeng Chemical Co., Ltd
HubeiwidelychemicaltechnologyCo.,Ltd

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