insoluble in EtOH; insoluble in H2O; ≥20.55 mg/mL in DMSO
form
solid
pka
12.54±0.40(Predicted)
color
White to gray
Description
Entospletinib (GS-9973) is an orally bioavailable, selective Syk inhibitor with IC50 of 7.7 nM in a cell-free assay and showed 13-to >1000-fold cellular selectivity for Syk over other kinases(including Jak2, ckit, Flt3, Ret, KDR) as assessed by target protein phosphorylation or functional response.
