Olaparib

$28 - $2147.1

Product nameOlaparib
Cas No763113-22-0
MFC24H23FN4O3
MW434.46
EINECS642-941-5
MDL NumberMFCD13185161

Synonyms

1-(Cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)Methyl]-2-fluorobenzoyl]piperazin;Olaparid AZD2281;4-[[3-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]Methyl]-1(2H)-phthalazinone;KU 59436;AZD2281(olaparib)/AZD-2281;AZD2281(olaparib);4-(3-(1-(cyclopropanecarbonyl)piperazine-4-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one;Olaparib-D8

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Price

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TCI Chemical Cayman Chemical Arctom Crysdot AccelPharmtech AvaChem TRC Usbiological Biorbyt Ltd ApexBio Technology Matrix Scientific AK Scientific Adipogen Life Sciences Axon Medchem Medical Isotopes, Inc. ChemScene American Custom Chemicals Corporation Biosynth DC Chemicals
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1unit 5mg 10mg 20mg 25mg 50mg 2x25mg 100mg 200mg 250mg 500mg 1g 2g 5g 10g 10mm*1mlindmso 10mm(in1mldmso) 25g evaluationsample

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Brand	Packaging	Price	Product name
AccelPharmtech CF1283	1G	$130	Olaparib
AccelPharmtech CF1283	1G	$130	Olaparib
AccelPharmtech CF1283	5G	$230	Olaparib
AccelPharmtech CF1283	5G	$230	Olaparib
AccelPharmtech CF1283	10G	$1050	Olaparib
AccelPharmtech CF1283	10G	$1050	Olaparib
AccelPharmtech CF1283	25G	$1910	Olaparib
AccelPharmtech CF1283	25G	$1910	Olaparib
Adipogen Life Sciences CDX-O0144-G001	1g	$460	Olaparib
Adipogen Life Sciences SYN-3043-M100	100mg	$594	Olaparib

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Properties

Density	1.43
storage temp.	-20°C
solubility	Soluble in DMSO (up to 33 mg/ml) or in Ethanol (up to 1.7 mg/ml)
pka	12.07±0.40(Predicted)
form	solid
color	Off-white
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChI	1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13-14,16,26H,6-7,9-12H2,(H,27,30)
InChIKey	FDLYAMZZIXQODN-UHFFFAOYSA-N
SMILES	C1(=O)C2=C(C=CC=C2)C(CC2=CC=C(F)C(C(N3CCN(C(C4CC4)=O)CC3)=O)=C2)=NN1
CAS DataBase Reference	763113-22-0

Safety Information

Symbol(GHS)

Signal word

Danger

Hazard statements

H314：Causes severe skin burns and eye damage

Precautionary statements

P260：Do not breathe dust/fume/gas/mist/vapours/spray.

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331：IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353：IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P363：Wash contaminated clothing before reuse.

P405：Store locked up.

P501：Dispose of contents/container to..…

Description

Many of the products generated by alkylating agents on DNA can be efficiently repaired by normal base excision repair (BER). Some poly(ADP-ribose) polymerases (PARPs) assist in the repair of single-strand DNA nicks, an important step in BER. Olaparib is a potent inhibitor of PARP1 and PARP2 (IC50 = 5 and 1 nM, respectively) but is less effective against the PARP tankyrase-1 (IC50 = 1.5 μM). It can be used in cells and in animals, alone or in combination therapy with alkylating agents, to block BER and increase cancer cell death.

Related product price

2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide $28-4644 BMN 673 $28-2839 871700-17-3 $28-4391.1

Suppliers and manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd

$70.00/1kg

Olaparib

CAS:763113-22-0
Hebei Yanxi Chemical Co., Ltd.

$0.00/1kg

Olaparib

CAS:763113-22-0
RongNa Biotechnology Co.,Ltd

$1.00/1g

Olaparib

CAS:763113-22-0
HangZhou RunYan Pharma Technology Co.,LTD.

$0.00/10g

Olaparib

CAS:763113-22-0
shandong perfect biotechnology co.ltd

$0.00/1g

Olaparib (AZD2281)

CAS:763113-22-0
Guangzhou TongYi biochemistry technology Co.,LTD
Zhengzhou Anhuida Chemical Co., Ltd
Seasons Biotechnology Co., Ltd.
Hefei TianRui Pharmaceutical Chemical Co., Ltd.
SHANDONG BOYUAN PHARMACEUTICAL CO., LTD.

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