Entacapone

$5 - $1957.73

Product nameEntacapone
Cas No130929-57-6
MFC14H15N3O5
MW305.29
EINECS212-686-0
MDL NumberMFCD00866580

Synonyms

(E)-2-Cyano-3-(3，4-dihydroxy-5-nitrophenyl)-N，N-diethyl-2-pmpenamide;Entacapone (150 mg);(2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enaMide;2-PropenaMide,2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-, (2E)-;Entacapone (isomer E);(E)-2-cyano-3-(5-(dihydroxyamino)-3,4-dioxocyclohexa-1,5-dienyl)-N,N-diethylacrylamide;ENTACAPONE;2-cyano-3-(5-dihydroxyamino-3,4-dioxo-1-cyclohexa-1,5-dienyl)-n,n-diethyl-prop-2-enamide

show less show more

Price

40 prices

Brand less more

Sigma-Aldrich Cayman Chemical CSNpharm Crysdot AvaChem Tocris TRC Usbiological Biorbyt Ltd ApexBio Technology AK Scientific Adipogen Life Sciences Axon Medchem Medical Isotopes, Inc. ChemScene American Custom Chemicals Corporation Biosynth Carbosynth Ambeed
Package less more

10mm(in1mldmso) 5mg 50 10mg 25mg 50mg 100mg 200mg 250mg 1g y0001249 10g 10 5g

Clear All Done

Brand	Packaging	Price	Product name
Adipogen Life Sciences AG-CR1-3708-M005	5mg	$25	Entacapone
AK Scientific J90011	100mg	$75	Entacapone
AK Scientific G843	250mg	$201	Entacapone
Ambeed A102154	5g	$107	(E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide
Ambeed A102154	50mg	$5	(E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide
American Custom Chemicals Corporation API0002552	1G	$1957.73	ENTACAPONE
ApexBio Technology A4168	10mg	$50	Entacapone
ApexBio Technology A4168	10mM(in 1mL DMSO)	$50	Entacapone
ApexBio Technology A4168	100mg	$150	Entacapone
AvaChem 2442	100mg	$129	Entacapone

1of4

Properties

Melting point	162-1630C
Boiling point	526.6±50.0 °C(Predicted)
Density	1.392±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: soluble20mg/mL, clear
form	powder
pka	pKa ~4.5(at 25℃)
color	white to light brown
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChIKey	JRURYQJSLYLRLN-BJMVGYQFSA-N
CAS DataBase Reference	130929-57-6(CAS DataBase Reference)

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H315：Causes skin irritation

H319：Causes serious eye irritation

Precautionary statements

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313：IF SKIN irritation occurs: Get medical advice/attention.

P337+P313：IF eye irritation persists: Get medical advice/attention.

Description

Catechol O-methyltransferase (COMT) is a key enzyme involved in the degradation of catecholamines including dopamine, epinephrine, and norepinephrine. COMPT metabolizes L-3,4-dihydroxyphenylalanine (L-DOPA) to 3-O-methyldopa (3-OMD), and then further to vanillactic acid, which is excreted in urine. Entacapone is a peripherally acting, selective and reversible COMT inhibitor with IC50 values of 150-300 nM in rat liver (Ki = 145 nM) and 10-20 nM in rat brain tissues. It was designed as an adjuvant to L-DOPA/dopa decarboxylase inhibitor treatment for Parkinson’s disease. Peripheral COMT inhibition with entacapone can decrease 3-OMD levels in the rat brain by 16-52% and prolong the bioavailability of L-DOPA in patients with Parkinson’s disease.

Related product price

2809-21-4 $5-1105.79 Diethyl oxalate $5-1000 Diethyl malonate $5-3732

Suppliers and manufacturers

Hebei Yanxi Chemical Co., Ltd.

$40.00/1kg

Entacapone

CAS:130929-57-6
Henan Bao Enluo International TradeCo.，LTD

$50.00/1kg

Entacapone

CAS:130929-57-6
career henan chemical co

$2.00/1kg

Entacapone

CAS:130929-57-6
Capot Chemical Co.,Ltd.
Henan Tianfu Chemical Co.,Ltd.
Hubei Jusheng Technology Co.,Ltd.
Shandong chuangyingchemical Co., Ltd.
BOC Sciences
Chongqing Chemdad Co., Ltd
CONIER CHEM AND PHARMA LIMITED

More related product prices

2809-21-4
Diethyl oxalate
Diethyl malonate
Ethylene glycol diethyl ether
Mefenpyr-diethyl

Sodium 3-nitrobenzenesulphonate
p-Nitrobenzoic acid
Entecavir
Entecavir hydrate
3,5-DINITROCATECHOL

116313-85-0
CIS-ENTACAPONE
Diethyl ether
Nitrobenzene
1,3-Dinitrobenzene

Acrylamide
N,N-DIETHYLACRYLAMIDE
Entacapone
DIETHYL-D10-AMINE
Tolcapone

1of4

Send Inquriy