AEG 3482 is a cell-permeable imidazothiadiazole compound that activates cellular transcription factor HSF1 by binding to HSP90 and disrupting its association with HSF1. AEG 3482 has been shown to induce HSF1-dependent expression of HSP70 and HSP25 and effectively block NRAGE- and p75NTR-mediated JNK activation and apoptosis in PC12 cells in a dose-dependent manner (>90% inhibition at 40 μM).
