Амитраз
- английское имяAmitraz
- CAS №33089-61-1
- CBNumberCB9680920
- ФормулаC19H23N3
- мольный вес293.41
- EINECS251-375-4
- номер MDLMFCD00069396
- файл Mol33089-61-1.mol
химическое свойство
| Температура плавления | 86-87°C |
| Температура кипения | 425.25°C (rough estimate) |
| плотность | 1.1280 |
| давление пара | 3.4×10-4 Pa (25 °C) |
| показатель преломления | 1.5892 (estimate) |
| температура хранения | Sealed in dry,Store in freezer, under -20°C |
| растворимость | DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml; DMSO: 20 mg/ml; Ethanol: 2 mg/ml |
| пка | 4.2 (weak base) |
| Растворимость в воде | 0.08 mg l-1 |
| форма | Powder/Solid |
| цвет | White |
| λмакс | 247nm(lit.) |
| Мерк | 14,486 |
| ИнЧИКей | QXAITBQSYVNQDR-ZIOPAAQOSA-N |
| Справочник по базе данных CAS | 33089-61-1(CAS DataBase Reference) |
| Рейтинг продуктов питания EWG | 4-5 |
| FDA UNII | 33IAH5017S |
| Предложение 65 Список | Amitraz |
| Справочник по химии NIST | Amitraz(33089-61-1) |
| Система регистрации веществ EPA | Amitraz (33089-61-1) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
больше
| Коды опасности | Xn;N,N,Xn | |||||||||
| Заявления о рисках | 22-43-48/22-50/53 | |||||||||
| Заявления о безопасности | 22-24-36/37-60-61 | |||||||||
| РИДАДР | UN 3077 | |||||||||
| WGK Германия | 3 | |||||||||
| RTECS | ZF0480000 | |||||||||
| Класс опасности | 9 | |||||||||
| Группа упаковки | III | |||||||||
| кода HS | 29252900 | |||||||||
| Банк данных об опасных веществах | 33089-61-1(Hazardous Substances Data) | |||||||||
| Токсичность | LD50 in male rats, female mice, rabbits, guinea pigs, bobwhite quail (mg/kg): 800, >1600, >100, >400, 788 orally; LD50 in rabbits, male rats (mg/kg): >200, >1600 dermally; LC50 (48 hr) in rainbow trout, Japanese carp: 3.3, 1.2 ppm (Labonne) | |||||||||
| NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
предупреждение
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вредная бумага
H302：Вредно при проглатывании.
H317：При контакте с кожей может вызывать аллергическую реакцию.
H410：Чрезвычайно токсично для водных организмов с долгосрочными последствиями.
H373：Может поражать органы (Нервная система) в результате многократного или продолжительного воздействия при вдыхании.
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оператор предупредительных мер
P260：Не вдыхать газ/ пары/ пыль/ аэрозоли/ дым/ туман.
P273：Избегать попадания в окружающую среду.
P280：Использовать перчатки/ средства защиты глаз/ лица.
P301+P312：ПРИ ПРОГЛАТЫВАНИИ: Обратиться за медицинской помощью при плохом самочувствии.
P302+P352：ПРИ ПОПАДАНИИ НА КОЖУ: Промыть большим количеством воды.
P314：В случае плохого самочувствия обратиться к врачу.
Амитраз химические свойства, назначение, производство
Химические свойства
Amitraz forms colorless needle-like crystals. Liquid formulations may contain flammable organic solvents.Использование
Amitraz is an antiparasitic used to control red spider mites, leaf miners and scale insects. This compound is active by inhibiting the targets monoaminooxidase enzyme.Определение
ChEBI: A tertiary amino compound that is 1,3,5-triazapenta-1,4-diene substituted by a methyl group at position 3 and 2,4-dimethylphenyl groups at positions 1 and 5.Общее описание
White monoclinic crystals. Melting point 187-189°F (86-87°C). Insoluble in water. Used as an acaricide, insecticide and treatment of demodectic mange in dogs.Реакции воздуха и воды
Insoluble in water.Профиль реактивности
Unstable in acid.Сельскохозяйственное использование
Insecticde, Acaricide, Veterinary medicine: Registered for control of pear psylla on pears, whitefly and mites on pears and cotton; cattle, dogs, sheep, and hog dip to control ticks, mange mites, lice and other pests. Not permitted on apples. Used to control red spider mites, leaf miners, scale insects, and aphids. Also used on cotton to control bollworms, white fly, leaf worms, and tobacco budworms. Not registered for use in EU countriesТорговое название
AAZDIENO®; ACARAC®; ACADREX®; ARMY®; AZODIENO®; BAAM®; BOOTS BTS 27419®; BTS 27,419®; BUMETRAN®; COYOTE®; DANICUT®; ECTODEX®; EDRIZAN®; EDRIZAR®; GARIAL®; ISTAMBUL®; MITABAN®; MITAC®; OVASYN®; OVIDREX®; PARSEC®; ROTRAZ®; SENDER®; TAC-PLUS®; TACTIK®; TRIATIX®; TRIATOX®; TUDY®; VAPCOZIN TAKTIC®; UPJOHN U-36059®Фармаколо?гия
The mechanism of action of amitraz has not been completely elucidated, and, presently, a dual mode of action appearsmost likely. Firstly, the enzymemonoamine oxidase, which metabolizes neurotransmitter amines in mites and ticks, is inhibited. Secondly, octopamine receptors in the central nervous system of ectoparasites are activated by amitraz, thereby modifying tonic muscle contractions. The effect of amitraz is to induce increased neuronal activity, abnormal behavior, detachment, and death of mites and ticks.Возможный контакт
Those engaged in the manufacture, formulation and application of this insecticide and acaricide. A rebuttable presumption against registration for amitraz was issued on April 6, 1977 by United States Environmental Protection Agency on the basis of oncogenicity. Incompatibilities: Keep away from strong oxidizers and strong acids. Acids may render this material unstable.Метаболический путь
14C-Amitraz is applied on lemons grown under glasshouse conditions at final harvest and the applied radioactivity is quantitatively recovered, predominantly in the peel (86%). The total residue at harvest contains amitraz, N-methyl-N'-(2,4-xylyl)formamidine, and formyl-2',4'-xylydine and conjugates of 4-amino- m-toluic acid and the conjugated metabolites which are convertible to 2,4-xylidine. Amitraz is readily hydrolyzed at low pH values, forming acid-stable formyl-2,4-xylydine which can be further hydrolyzed to 2,4-xylidine.Метаболизм
Amitraz is poorly absorbed when applied topically to animals. By contrast, orally administered amitraz is rapidly and extensively absorbed. The metabolism and excretion of amitraz are also rapid. It is hydrolyzed to N-(2,4-dimethylphenyl)-N -methyl formamidine and 2,4- dimethyl formamidine and the final product, 4-amino-3- methylbenzoic acid, is converted to non-toxic conjugates. The latter are excreted in the urine and, to a lesser extent, in bile.Перевозки
UN2763 Triazine pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.Несовместимости
Those engaged in the manufacture, formulation and application of this insecticide and acaricide. A rebuttable presumption against registration for amitraz was issued on April 6, 1977 by United States Environmental Protection Agency on the basis of oncogenicity. Incompatibilities: Keep away from strong oxidizers and strong acids. Acids may render this material unstable.Утилизация отходов
In accordance with 40CFR 165 recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.Амитраз запасные части и сырье
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Амитраз Обзор)
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