Бримонидин

Описание

Launched in the US for open-angle glaucoma and ocular hypertension, brimonidine is a relatively selective and potent α_2a,-adrenergic agonist with low affinity for the imidazoline l₁ receptor. Topical application reduces intraocular pressure. This bypasses any central hypotensive effects at the l₁ receptor (which can also give rise to a decrease in blood pressure and heart rate) if given systemically, since topical application results in low plasma levels concomitant with rapid systemic elimination. Brimonidine can be prepared in a four-step sequence from 4-nitrophenylenediamine.

Химические свойства

Yellow Solid

Использование

a2-Adrenoceptor agonist. Antiglaucoma

Опасность

A poison by ingestion.

Биологическая активность

Full α 2 adrenergic agonist. Centrally active following systemic administration in vivo . Also available as part of the α 2 -Adrenoceptor Tocriset™ and Mixed Adrenergic Tocriset™ .