Аминептин
- английское имяAmineptine
- CAS №57574-09-1
- CBNumberCB8897347
- ФормулаC22H27NO2
- мольный вес337.46
- EINECS260-818-0
- файл Mol57574-09-1.mol
химическое свойство
| Температура плавления | 209 °C |
| Температура кипения | 509.9±50.0 °C(Predicted) |
| плотность | 1.13±0.1 g/cm3(Predicted) |
| растворимость | DMSO (Slightly), Methanol (Slightly) |
| форма | Solid |
| пка | 4.75±0.10(Predicted) |
| цвет | White to Pale Yellow |
| FDA UNII | 27T1I13L6G |
| Код УВД | N06AA19 |
| Справочник по химии NIST | Amineptine(57574-09-1) |
Аминептин химические свойства, назначение, производство
Использование
Amineptine is used as an atypical tricyclic antidepressant. Amineptine selectively inhibits the reuptake of dopamine and to a lesser extent norepinephrine.Определение
ChEBI: A carbocyclic fatty acid that is 5-aminoheptanoic acid in which one of the hydrogens attached to the nitrogen is replaced by a 10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yl group. A tricyclic antidepressant, it w s never approved in the US and was withdrawn from the French market in 1999 due to concerns over abuse, dependence and severe acne.Ферментативный ингибитор
This synthetic dopamine reuptake inhibitor (FW = 338.47 g/mol; CAS 57574-09-1), also known by the trade names Survector?, Maneon?, Directim?, Neolior?, Provector?, and Viaspera? as well as its IUPAC name, 7-[(10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5-yl)amino]heptanoic acid, significantly reduces the effect of 6-hydroxy-dopamine on brain dopamine, increases striatal homovanillic acid concentrations, and shows cross-tolerance. Despite these amphetamine-like properties, amineptine does not alter brain noradrenaline or acetylcholine concentrations, suggesting amineptine is a new type of antidepressant with a brain biochemical profile differing from that of other drugs used in depressive disorders. Amineptine is also a norepinephrine reuptake inhibitor. This agent is also ineffective in reducing amphetamine withdrawal symptoms or craving. Amineptine failed to secure FDA approval and is not a duly authorized drug in the U.S.