Витамин Е сукцинат полиэтиленгликоля (TPGS)
- английское имяTocofersolan
- CAS №9002-96-4
- CBNumberCB8396198
- Формула(C2H4O)nC33H54O5
- мольный вес0
- EINECS211-836-2
- номер MDLMFCD00146616
- файл Mol9002-96-4.mol
химическое свойство
Температура плавления | 34-38°C |
температура хранения | 2-8°C |
растворимость | H2O: soluble1g/10 mL, clear to faintly turbid, colorless to faintly yellow |
форма | Solid |
цвет | White to Pale Yellow Waxy |
InChI | InChI=1S/C34H56O6/c1-23(2)12-9-13-24(3)14-10-15-25(4)16-11-20-34(8)21-19-29-28(7)32(26(5)27(6)33(29)40-34)39-31(37)18-17-30(36)38-22-35/h23-25,35H,9-22H2,1-8H3 |
ИнЧИКей | WFWQYXBTWIHIIW-UHFFFAOYSA-N |
SMILES | C(=O)(OC1C(C)=C2CCC(C)(CCCC(CCCC(CCCC(C)C)C)C)OC2=C(C)C=1C)CCC(=O)OCO |
LogP | 9.745 (est) |
Рейтинг продуктов питания EWG | 1 |
FDA UNII | O03S90U1F2 |
Словарь наркотиков NCI | tocophersolan |
Код УВД | A11HA08 |
Витамин Е сукцинат полиэтиленгликоля (TPGS) химические свойства, назначение, производство
Химические свойства
Vitamin E polyethylene glycol succinate is a synthetic product. It is available as a white to light-brown, waxy solid and is practically tasteless. Chemically, it is a mixture composed principally of monoesterified polyethylene glycol 1000, the diesterified polyethylene glycol 1000, free polyethylene glycol 1000, and free tocopherol.Методы производства
Vitamin E polyethylene glycol succinate is prepared by esterification of the acid group of crystalline D-a-tocopheryl acid succinate by polyethylene glycol 1000.Фармацевтические приложения
Vitamin E polyethylene glycol succinate is an esterified vitamin E (tocopherol) derivative primarily used as a solubilizer or emulsifying agent because of its surfactant properties. Structurally, it is amphipathic and hydrophilic, unlike the tocopherols, and therefore it is a water-soluble derivative that can be used in pharmaceutical formulations such as capsules, tablets, hot-melt extrusion, microemulsions, topical products, and parenterals. One of the most important applications is its use as a vehicle for lipid-based drug delivery formulations. It can also be used as a source of vitamin E.Vitamin E polyethylene glycol succinate has been characterized with respect to its mechanism of action and studied as a Pglycoprotein inhibitor.
Безопасность
Vitamin E polyethylene glycol succinate has been used at levels of 280 mg/capsule in the product Agenerase (amprenavir), which was dosed at 8 capsules (2240mg vitamin E TPGS) per day. An additional assessment of the safety of vitamin E polyethylene glycol succinate has been published, which includes a report showing no-observed-adverse-effect-level (NOAEL) in rats of 1000 mg/kg/day.хранилище
Vitamin E polyethylene glycol succinate is stable at ambient room temperature for up to 4 years. It reacts with alkalis and acids. Aqueous solutions of vitamin E polyethylene glycol succinate are stable over a pH range of 4.5–7.5 and can be further stabilized with propylene glycol.Несовместимости
Vitamin E polyethylene glycol succinate is incompatible with strong acids and strong alkalis.Регуляторный статус
GRAS listed. Included in the FDA Inactive Ingredients Database (ophthalmic solution or drops; oral capsules, solution, tablet; topical solution or drops). Included in the Canadian List of Acceptable Non-medicinal Ingredients.Витамин Е сукцинат полиэтиленгликоля (TPGS) запасные части и сырье
Витамин Е сукцинат полиэтиленгликоля (TPGS) поставщик
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