Циклогексанон
- английское имяCyclohexanone
- CAS №108-94-1
- CBNumberCB8347660
- ФормулаC6H10O
- мольный вес98.14
- EINECS203-631-1
- номер MDLMFCD00001625
- файл Mol108-94-1.mol
химическое свойство
| Температура плавления | -47 °C (lit.) |
| Температура кипения | 155 °C (lit.) |
| плотность | 0.947 g/mL at 25 °C (lit.) |
| плотность пара | 3.4 (vs air) |
| давление пара | 3.4 mm Hg ( 20 °C) |
| показатель преломления | n |
| FEMA | 3909 | CYCLOHEXANONE |
| Fp | 116 °F |
| температура хранения | Store at +5°C to +30°C. |
| растворимость | 90g/l |
| пка | 17(at 25℃) |
| форма | Liquid |
| цвет | APHA: ≤10 |
| Относительная полярность | 0.281 |
| РН | 7 (70g/l, H2O, 20℃) |
| Запах | Like peppermint and acetone. |
| Пределы взрываемости | 1.1%, 100°F |
| Odor Type | minty |
| Биологические источники | synthetic |
| Растворимость в воде | 150 g/L (10 ºC) |
| Мерк | 14,2726 |
| Номер JECFA | 1100 |
| БРН | 385735 |
| констант закона Генри | 1.2 x 10-5 atm?m3/mol at 25 °C (Hawthorne et al., 1985) 6.92 x 10-5 atm?m3/mol at 60.00 °C, 10.7 at 70.00 °C, 16.4 at 80.00 °C (headspace-GC, Hovorka et al., 2002) |
| Пределы воздействия | TLV-TWA 100 mg/m3 (25 ppm) (ACGIH); IDLH 5000 ppm (NIOSH). |
| Диэлектрическая постоянная | 18.2（20℃） |
| Стабильность | Stable. Combustible. Incompatible with strong oxidizing agents. |
| LogP | 0.86 at 25℃ |
| Вещества, добавляемые в пищу (ранее EAFUS) | CYCLOHEXANONE |
| Справочник по базе данных CAS | 108-94-1(CAS DataBase Reference) |
| Рейтинг продуктов питания EWG | 10 |
| FDA UNII | 5QOR3YM052 |
| МАИР | 3 (Vol. 47, 71) 1999 |
| Справочник по химии NIST | Cyclohexanone(108-94-1) |
| Система регистрации веществ EPA | Cyclohexanone (108-94-1) |
| UNSPSC Code | 41116107 |
| NACRES | NB.61 |
больше
| Коды опасности | Xn | |||||||||
| Заявления о рисках | 10-20-41-38-20/21/22 | |||||||||
| Заявления о безопасности | 25-36/37/39-26 | |||||||||
| РИДАДР | UN 1915 3/PG 3 | |||||||||
| OEB | A | |||||||||
| OEL | TWA: 25 ppm (100 mg/m3) [skin] | |||||||||
| WGK Германия | 1 | |||||||||
| RTECS | GW1050000 | |||||||||
| Температура самовоспламенения | 788 °F | |||||||||
| TSCA | Yes | |||||||||
| кода HS | 2914 22 00 | |||||||||
| Класс опасности | 3 | |||||||||
| Группа упаковки | III | |||||||||
| Банк данных об опасных веществах | 108-94-1(Hazardous Substances Data) | |||||||||
| Токсичность | LD50 orally in rats: 1.62 ml/kg (Smyth) | |||||||||
| ИДЛА | 700 ppm | |||||||||
| NFPA 704: |
|
рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H315：При попадании на кожу вызывает раздражение.
H318：При попадании в глаза вызывает необратимые последствия.
H226：Воспламеняющаяся жидкость. Пары образуют с воздухом взрывоопасные смеси.
H302+H312+H332：Вредно при проглатывании, при попадании на кожу или при вдыхании.
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оператор предупредительных мер
P210：Беречь от тепла, горячих поверхностей, искр, открытого огня и других источников воспламенения. Не курить.
P280：Использовать перчатки/ средства защиты глаз/ лица.
P301+P312：ПРИ ПРОГЛАТЫВАНИИ: Обратиться за медицинской помощью при плохом самочувствии.
P303+P361+P353：ПРИ ПОПАДАНИИ НА КОЖУ (или волосы): Снять/удалить немедленно всю загрязненную одежду. Промыть кожу водой.
P304+P340+P312：ПРИ ВДЫХАНИИ: Свежий воздух, покой. Обратиться за медицинской помощью при плохом самочувствии.
P305+P351+P338：ПРИ ПОПАДАНИИ В ГЛАЗА: Осторожно промыть глаза водой в течение нескольких минут. Снять контактные линзы, если Вы ими пользуетесь и если это легко сделать. Продолжить промывание глаз.
Циклогексанон химические свойства, назначение, производство
Описание
Cyclohexanone, a colorless liquid is a cyclic ketone. It is an important building block for the synthesis of a variety of organic compounds. Majority of the cyclohexanone synthesized is utilized as an intermediate in the synthesis of nylon.Used as a polyvinyl chloride (PVC) solvent, cyclohexanone caused contact dermatitis in a woman manufacturing PVC fluidotherapy bags. Cyclohexanone probably does not cross react with cyclohexanone resin. A cyclohexanone-derived resin used in paints and varnishes caused contact dermatitis in painters.
Химические свойства
Cyclohexanone is a water-white to slightly yellow liquid with a peppermint-like or acetone-like odor. The Odor Threshold is 0.12 0.24 ppm in air.Физические свойства
Clear, colorless to pale yellow, oily liquid with a peppermint-like odor. Experimentally determined detection and recognition odor threshold concentrations were identical: 480 μg/m3 (120 ppmv) (Hellman and Small, 1974).Вхождение
Reported present in Cistus labdaniferus.Использование
Cyclohexanone is used in the productionof adipic acid for making nylon; in thepreparation of cyclohexanone resins; and asa solvent for nitrocellulose, cellulose acetate,resins, fats, waxes, shellac, rubber, and DDT..Определение
ChEBI: A cyclic ketone that consists of cyclohexane bearing a single oxo substituent.Общее описание
A colorless to pale yellow liquid with a pleasant odor. Less dense than water . Flash point 111°F. Vapors heavier than air. Used to make nylon, as a chemical reaction medium, and as a solvent.Реакции воздуха и воды
Flammable. Soluble in water.Профиль реактивности
Cyclohexanone forms an explosive peroxide with H2O2, and reacts vigorously with oxidizing materials (nitric acid).Угроза здоровью
The toxicity of cyclohexanone in test specieswas found to be low to moderate. Exposureto its vapors can produce irritation in the eyesand throat. Splashing into the eyes can damagethe cornea. Throat irritation in humansmay occur from 3–5 minute exposure to a50-ppm concentration in air. The symptomsof chronic toxicity in animals from its inhalationwere liver and kidney damage, as wellas weight loss. However, its acute toxicitywas low below 3000 ppm. The symptomsin guinea pigs were lacrimation, salivation,lowering of heart rate, and narcosis. Exposureto 4000 ppm for 4–6 hours was lethalto rats and guinea pigs.The oral toxicity of this compound waslow. Ingestion may cause narcosis and depressionof the central nervous system. It canbe absorbed through the skin.
LD50 value, dermal (rabbits): 1000 mg/kg
LD50 value, intraperitoneal (rats): 1130 mg/kg.
Пожароопасность
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.Химическая реактивность
Reactivity with Water No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.Контактные аллергены
Used as a polyvinyl chloride solvent, cyclohexanone caused contact dermatitis in a woman manufacturing PVC fluidotherapy bags. Cyclohexanone probably does not cross-react with cyclohexanone resin. A cyclohexanone-derived resin used in paints and varnishes caused contact dermatitis in paintersПрофиль безопасности
Suspected carcinogen. Moderately toxic by ingestion, inhalation, subcutaneous, intravenous, and intraperitoneal routes. A skin and severe eye irritant. Human systemic effects by inhalation: changes in the sense of smell, conjunctiva irritation, and unspecified respiratory system changes. Human irritant by inhalation. Mdd narcotic properties have also been ascribed to it. Human mutation data reported. Experimental reproductive effects. Flammable liquid when exposed to heat or flame; can react vigorously with oxidizing materials. Slight explosion hazard in its vapor form, when exposed to flame.Reaction with hydrogen peroxide + nitric acid forms an explosive peroxide. To fight fire, use alcohol foam, dry chemical, or COa. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES and CYCLOHEXANE.Возможный контакт
May form explosive mixture with air. Contact with oxidizing agents or nitric acid may cause a violent reaction. Do not use brass, copper, bronze, or lead fittings. Attacks many coatings and plastic materials.Канцерогенность
IARC considers the animal data for cyclohexanone as inadequate evidence of carcinogenicity and listed cyclohexanone as not classifiable for carcinogenicity (IARC Category 3).Экологическая судьба
Biological. In activated sludge inoculum, 96.0% COD removal was achieved. The average rate of biodegradation was 30.0 mg COD/g?h (Pitter, 1976).Photolytic. Atkinson (1985) reported an estimated photooxidation rate constant of 1.56 x 10-11 cm3/molecule?sec for the reaction of cyclohexanone and OH radicals in the atmosphere at 298 K. Chemical/Physical. Cyclohexanone will not hydrolyze because it has no hydrolyzable functional group.
At an influent concentration of 1,000 mg/L, treatment with GAC resulted in effluent concentration of 332 mg/L. The adsorbability of the carbon used was 134 mg/g carbon (Guisti et al., 1974). Similarly, at influent concentrations of 10, 1.0, 0.1, and 0.01 mg/L, the GAC adsorption capacities were 36, 6.2, 1.1, and 0.19 mg/g, respectively (Dobbs and Cohen, 1980).
Перевозки
UN1915 Cyclohexanone, Hazard Class: 3; Labels: 3-Flammable liquid.Методы очистки
Dry cyclohexanone with MgSO4,CaSO4, Na2SO4 or Linde type 13X molecular sieves, then distil it. Cyclohexanol and other oxidisable impurities can be removed by treatment with chromic acid or dilute KMnO4. More thorough purification is possible by conversion to the bisulfite addition compound, or the semicarbazone, followed by decomposition with Na2CO3 and steam distillation. [For example, equal weights of the bisulfite adduct (crystallised from water) and Na2CO3 are dissolved in hot water and, after steam distillation, the distillate is saturated with NaCl and extracted with Et2O which is then dried (anhydrous MgSO4 or Na2SO4), filtered and the solvent evaporated prior to further distillation.] FLAMMABLE [Beilstein 7 III 14, 7 IV 15.]Несовместимости
May form explosive mixture with air. Contact with oxidizing agents or nitric acid may cause a violent reaction. Do not use brass, copper, bronze, or lead fittings. Attacks many coatings and plastic materials.Утилизация отходов
Dissolve or mix the material with a combustible solvent and burn in a chemical incinera- tor equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.Циклогексанон запасные части и сырье
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