Sodium propylparaben

Химические свойства

White or almost white, hygroscopic, crystalline powder.

Использование

Sodium Propylparaben is a preservative. Sodium Propylparaben is also an excipient used in various pharmaceutical formulations.

Методы производства

Propylparaben sodium is produced from benzoic acid.

Фармацевтические приложения

Propylparaben sodium is used as an antimicrobial or antifungal preservative in oral pharmaceuticals and in many water-based cosmetics. It is generally used in combination with other paraben esters.

Контактные аллергены

This substance is one of the parabens family. Parabens are esters formed by p-hydroxybenzoic acid and an alcohol. They are largely used as biocides in cosmetics and toiletries, medicaments, or food. They have synergistic power with other biocides. Parabens can induce allergic contact dermatitis, mainly in chronic dermatitis and wounded skin.

Безопасность

Propylparaben sodium is used in oral pharmaceuticals and cosmetics. The pure form is toxic by the IV route and moderately toxic by ingestion and the IP route. Propylparaben sodium may cause asthma, rashes, and hyperactivity.
LD50 (mouse, IP): 0.49 g/kg
LD50 (mouse, IV): 0.18 g/kg
LD50 (mouse, oral): 3.7 g/kg

хранилище

Propylparaben sodium is stable under normal conditions. It decomposes on heating. Store in a tightly closed container.

Несовместимости

The activity of propylparaben sodium can be adversely affected by the presence of other excipients or active ingredients, such as atropine, essential oils, iron, magnesium trisilicate, talc, polysorbate 80 and other nonionic surfactants, sorbitol, weak alkalis, and strong acids.

Регуляторный статус

Included in the FDA Inactive Ingredients Database (oral capsules, tablets, suspensions). Accepted for use as a food additive in Europe. Included in nonparenteral medicines (oral capsules, mixtures, orodispersible tablets, solutions and suspensions; cutaneous emulsions) licensed in the UK.