Этил бромацета
- английское имяEthyl bromoacetate
- CAS №105-36-2
- CBNumberCB6852654
- ФормулаC4H7BrO2
- мольный вес167
- EINECS203-290-9
- номер MDLMFCD00000191
- файл Mol105-36-2.mol
химическое свойство
| Температура плавления | -38 °C |
| Температура кипения | 159 °C(lit.) |
| плотность | 1.506 g/mL at 25 °C(lit.) |
| плотность пара | 5.8 (vs air) |
| давление пара | 2.6 mm Hg ( 25 °C) |
| показатель преломления | n |
| Fp | 118 °F |
| температура хранения | Store below +30°C. |
| растворимость | water: insoluble |
| форма | Liquid |
| цвет | Clear |
| Удельный вес | 1.506 |
| Запах | Pungent odour |
| Растворимость в воде | Miscible with ethanol, acetone, benzene and ethyl ether. Immiscible with water. |
| БРН | 506456 |
| Диэлектрическая постоянная | 9.75 |
| Стабильность | Stable. Combustible. Incompatible with strong oxidizing agents, water, strong acids. |
| ИнЧИКей | PQJJJMRNHATNKG-UHFFFAOYSA-N |
| Справочник по базе данных CAS | 105-36-2(CAS DataBase Reference) |
| Рейтинг продуктов питания EWG | 1-2 |
| FDA UNII | D20KFB313W |
| Справочник по химии NIST | Acetic acid, bromo-, ethyl ester(105-36-2) |
| Система регистрации веществ EPA | Acetic acid, 2-bromo-, ethyl ester (105-36-2) |
больше
| Коды опасности | T+ | |||||||||
| Заявления о рисках | 26/27/28 | |||||||||
| Заявления о безопасности | 26-45-7/9-1/2 | |||||||||
| РИДАДР | UN 1603 6.1/PG 2 | |||||||||
| WGK Германия | 1 | |||||||||
| RTECS | AF6000000 | |||||||||
| F | 19 | |||||||||
| TSCA | Yes | |||||||||
| Класс опасности | 6.1 | |||||||||
| Группа упаковки | II | |||||||||
| кода HS | 29159080 | |||||||||
| Банк данных об опасных веществах | 105-36-2(Hazardous Substances Data) | |||||||||
| NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H300+H310+H330：Смертельно при проглатывании, при контакте с кожей или при вдыхании.
H226：Воспламеняющаяся жидкость. Пары образуют с воздухом взрывоопасные смеси.
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оператор предупредительных мер
P210：Беречь от тепла, горячих поверхностей, искр, открытого огня и других источников воспламенения. Не курить.
P233：Держать в плотно закрытой/герметичной таре.
P240：Заземлить и электрически соединить контейнер и приемное оборудование.
P280：Использовать перчатки/ средства защиты глаз/ лица.
P303+P361+P353：ПРИ ПОПАДАНИИ НА КОЖУ (или волосы): Снять/удалить немедленно всю загрязненную одежду. Промыть кожу водой.
P304+P340+P310：ПРИ ВДЫХАНИИ: Свежий воздух, покой. Немедленно обратиться за медицинской помощью.
Этил бромацета химические свойства, назначение, производство
Химические свойства
Ethyl bromoacetate is a clear, colorless to light-yellow liquid and has a pungent odor. It is miscible with ethanol, ether, benzene and with other oxygenated and aromatic solvents, insoluble in water and partially decomposed by water.прикладной
Ethyl Bromoacetate is used as a synthetic organic chemical intermediate as well as a pharmaceutical and agricultural intermediate. It is used in the synthesis of metabolites of carcinogenic PAHs. It is also used in the preparation of steroidal antiestrogens through cyclic condensation. Ethyl Bromoacetate is a reactant in the preparation of antim icrobial and antioxidant coumarinyloxymethyl-thiadiazolone.Подготовка
Ethyl bromoacetate is commonly synthesized by sulfuric acid catalyzed esterification of monobromoacetic acid (MBAA). After reaction completion, excess acid is washed out and the product purified via distillation under reduced pressure if necessary (Stenger, 1978; Korhonen, 1984).Реакции
Ethyl bromoacetate on derivatisation reaction with p-t-butyl calix[4]arene yields 1,3-diester substituted calix[4]arene. It also undergoes Suzuki type cross-coupling reactions with arylboronic acids cocatalyzed by copper(I) oxide.Общее описание
Ethyl bromoacetate appears as a clear, colorless liquid. A lachrymator. Toxic by ingestion, inhalation and skin absorption; a strong irritant of the skin. Insoluble in water and soluble in alcohol, benzene, and ether. Specific gravity of 1.5.Реакции воздуха и воды
Flammable. Insoluble in water.Профиль реактивности
Ethyl bromoacetate is a halogenated ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.Опасность
Toxic by ingestion, inhalation, and skin absorption; strong irritant.Угроза здоровью
TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Bromoacetates and chloroacetates are extremely irritating/lachrymators. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.Пожароопасность
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.Профиль безопасности
A poison. An irritant to skin, eyes, and mucous membranes. Questionable carcinogen with experimental neoplastigenic data. Flammable liquid when exposed to heat, flame, and oxidizers. Will react with water or steam to produce toxic and corrosive fumes. To fight fire, use water as a fire blanket. When heated to decomposition or on contact with acid or acid fumes, it emits highly toxic fumes of Br-. See also BROMIDES.Возможный контакт
Used for making pharmaceuticals; as a warning gas in poisonous, odorless gasses; as a tear gasПеревозки
UN1603 Ethyl bromoacetate, Hazard class: 6.1; Labels: 6.1-Poisonous materials.Методы очистки
Wash the ester with saturated aqueous Na2CO3 (three times), 50% aqueous CaCl2 (three times) and saturated aqueous NaCl (twice). Dry with MgSO4, CaCl2 or CaCO3, and distil it. [Beilstein 2 IV 527.] LACHRYMATORY.Несовместимости
Vapor may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, and reducing agents. Esters are generally incompatible with nitrates. Moisture may cause hydrolysis or other forms of decomposition.Этил бромацета запасные части и сырье
сырьё
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Этил бромацета поставщик
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