Мепробамат
- английское имяMeprobamate
- CAS №57-53-4
- CBNumberCB6477952
- ФормулаC9H18N2O4
- мольный вес218.25
- EINECS200-337-5
- номер MDLMFCD00063428
- файл Mol57-53-4.mol
химическое свойство
| Температура плавления | 97-100°C |
| Температура кипения | 358.93°C (rough estimate) |
| плотность | 1.2004 (rough estimate) |
| показатель преломления | 1.4480 (estimate) |
| Fp | 11 °C |
| температура хранения | 2-8°C |
| растворимость | DMF: 50 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 30 mg/ml; Ethanol: 25 mg/ml |
| пка | 13.09±0.50(Predicted) |
| Растворимость в воде | 6.2g/L(25 ºC) |
| Стабильность | Stable. Combustible. Incompatible with strong oxidizing agents. |
| Справочник по базе данных CAS | 57-53-4(CAS DataBase Reference) |
| Рейтинг продуктов питания EWG | 1 |
| FDA UNII | 9I7LNY769Q |
| Предложение 65 Список | Meprobamate |
| Словарь наркотиков NCI | Mepron |
| Код УВД | N05BC01,N05BC51,N05CX01 |
| Справочник по химии NIST | 1,3-Propanediol, 2-methyl-2-propyl-, dicarbamate(57-53-4) |
| Система регистрации веществ EPA | Meprobamate (57-53-4) |
| Коды опасности | Xn,T,F | |||||||||
| Заявления о рисках | 22-39/23/24/25-23/24/25-11 | |||||||||
| Заявления о безопасности | 7-16-36/37-45 | |||||||||
| РИДАДР | UN 1230 3/PG 2 | |||||||||
| WGK Германия | 3 | |||||||||
| RTECS | TZ0175000 | |||||||||
| кода HS | 2924110000 | |||||||||
| Банк данных об опасных веществах | 57-53-4(Hazardous Substances Data) | |||||||||
| Токсичность | LD50 i.p. in mice: 800 mg/kg (Berger) | |||||||||
| NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
предупреждение
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вредная бумага
H302：Вредно при проглатывании.
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оператор предупредительных мер
P301+P312+P330：ПРИ ПРОГЛАТЫВАНИИ: Обратиться за медицинской помощью при плохом самочувствии. Прополоскать рот.
Мепробамат химические свойства, назначение, производство
Химические свойства
white crystalline powderИспользование
An anxiolytic. This is a controlled substance.Всемирная организация здравоохранения(ВОЗ)
Meprobamate, a bis-carbamate ester, was introduced in 1955 for the treatment of anxiety and was subsequently used as a sedative-hypnotic drug. Psychological and physical dependence can occur and abuse has been reported. Meprobamate is controlled under Schedule IV of the 1971 Convention on Psychotropic Substances. (Reference: (UNCPS4) United Nations Convention on Psychotropic Substances (IV), , , 1971)Общее описание
Meprobamate,2-methyl-2-propyltrimethylene dicarbamate, 2-methyl-2-propyl-1,3-propanediol dicarbamate (Equanil, Miltown), is officiallyindicated as an antianxiety agent. It is also a sedative–hypnotic agent. It has several overall pharmacological properties resembling those of benzodiazepines and barbiturates.The mechanism of action underlying anxiolytic effectsis unknown but may involve effects on conductivity inspecific brain areas.It does not appear to act through effectson GABAergic systems.The drug is effective againstabsence seizures and may worsen generalized tonic–clonicseizures.Реакции воздуха и воды
Insoluble in water.Профиль реактивности
Meprobamate is a carbamate ester. Carbamates are chemically similar to, but more reactive than amides. Like amides they form polymers such as polyurethane resins. Carbamates are incompatible with strong acids and bases, and especially incompatible with strong reducing agents such as hydrides. Flammable gaseous hydrogen is produced by the combination of active metals or nitrides with carbamates. Strongly oxidizing acids, peroxides, and hydroperoxides are incompatible with carbamates.Опасность
Central nervous system depressant, use restricted by law.Пожароопасность
Flash point data for Meprobamate are not available; however, Meprobamate is probably combustible.Клиническое использование
Meprobamate is also a centrally acting skeletal musclerelaxant. The agents in this group find use in several conditions,such as strains and sprains that may produce acutemuscle spasm. They have interneuronal blocking propertiesat the level of the spinal cord, which are said to bepartly responsible for skeletal muscle relaxation.Also,the general CNS depressant properties they possess maycontribute to, or be mainly responsible for, the skeletalmuscle relaxant activity.Профиль безопасности
Human poison by unspecified routes. Moderately toxic to humans and experimentally by ingestion. Experimental poison by intravenous, intraperitoneal, and subcutaneous routes. An experimental teratogen. Human systemic effects by ingestion: coma, blood pressure decrease, regional or general arteriolar constriction, dyspnea, cyanosis, respiratory depression, nausea or vomiting, and allergic skin dermatitis. Experimental reproductive effects. Mutation data reported. Implicated in aplastic anemia. Used as a tranquilizer. When heated to decomposition it emits toxic fumes of NOx.Методы очистки
Crystallise it from hot water, aqueous EtOH (m 104-105.5o) or xylene (m 104.1-105.3o). It can be an addictive drug. [Beilstein 3 IV 73.]