Тиофен
- английское имяThiophene
- CAS №110-02-1
- CBNumberCB5852798
- ФормулаC4H4S
- мольный вес84.14
- EINECS203-729-4
- номер MDLMFCD00005413
- файл Mol110-02-1.mol
химическое свойство
| Температура плавления | -38 °C (lit.) |
| Температура кипения | 84 °C (lit.) |
| плотность | 1.051 g/mL at 25 °C (lit.) |
| плотность пара | 2.9 (vs air) |
| давление пара | 40 mm Hg ( 12.5 °C) |
| показатель преломления | n |
| Fp | -9 °C |
| температура хранения | Store below +30°C. |
| растворимость | Miscible with carbon tetrachloride, heptane, pyrimidine, dioxane, toluene, and many organic solvents (quoted, Keith and Walters, 1992) |
| форма | powder |
| цвет | Clear |
| Удельный вес | 1.06 |
| Запах | at 0.10 % in propylene glycol. alliaceous garlic |
| Odor Type | sulfurous |
| Порог?обнаружения?запаха? | 0.00056ppm |
| Пределы взрываемости | 1.5-12.5%(V) |
| Растворимость в воде | INSOLUBLE |
| Мерк | 14,9353 |
| БРН | 103222 |
| констант закона Генри | 2.33 and 2.70 in distilled water and seawater, respectively (Przyjazny et al., 1983) |
| Диэлектрическая постоянная | 9.3（20℃） |
| Стабильность | Stable. Highly flammable. Incompatible with strong oxidizing agents, nitrates. |
| LogP | 1.81-1.86 at pH10 |
| Справочник по базе данных CAS | 110-02-1(CAS DataBase Reference) |
| Рейтинг продуктов питания EWG | 1 |
| FDA UNII | SMB37IQ40B |
| Справочник по химии NIST | Thiophene(110-02-1) |
| Система регистрации веществ EPA | Thiophene (110-02-1) |
больше
| Коды опасности | F,Xn,Xi,T | |||||||||
| Заявления о рисках | 45-46-11-20/21/22-41-52/53-36-20/22-37/38-22-48/20/21/22 | |||||||||
| Заявления о безопасности | 53-26-39-45-61-36/37/39-16-36 | |||||||||
| РИДАДР | UN 2414 3/PG 2 | |||||||||
| WGK Германия | 3 | |||||||||
| RTECS | XM7350000 | |||||||||
| Температура самовоспламенения | 743 °F | |||||||||
| Примечание об опасности | Irritant/Highly Flammable | |||||||||
| TSCA | Yes | |||||||||
| Класс опасности | 3 | |||||||||
| Группа упаковки | II | |||||||||
| кода HS | 29349990 | |||||||||
| Банк данных об опасных веществах | 110-02-1(Hazardous Substances Data) | |||||||||
| Токсичность | LD50 orally in Rabbit: 1400 mg/kg | |||||||||
| NFPA 704: |
|
рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H319：При попадании в глаза вызывает выраженное раздражение.
H302：Вредно при проглатывании.
H350：Может вызывать раковые заболевания.
H225：Легковоспламеняющаяся жидкость. Пары образуют с воздухом взрывоопасные смеси.
H340：Может вызывать генетические дефекты.
H412：Вредно для водных организмов с долгосрочными последствиями.
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оператор предупредительных мер
P202：Перед использованием ознакомиться с инструкциями по технике безопасности.
P210：Беречь от тепла, горячих поверхностей, искр, открытого огня и других источников воспламенения. Не курить.
P273：Избегать попадания в окружающую среду.
P301+P312：ПРИ ПРОГЛАТЫВАНИИ: Обратиться за медицинской помощью при плохом самочувствии.
P305+P351+P338：ПРИ ПОПАДАНИИ В ГЛАЗА: Осторожно промыть глаза водой в течение нескольких минут. Снять контактные линзы, если Вы ими пользуетесь и если это легко сделать. Продолжить промывание глаз.
P308+P313：ПРИ подозрении на возможность воздействия обратиться за медицинской помощью.
Тиофен химические свойства, назначение, производство
Химические свойства
Thiophene is a colourless to pale yellow liquid that has an odor similar to benzene. It is a heterocyclic compound with a five-membered ring containing four carbon atoms and one sulfur atom. The ring system is also known as a thienyl ring. It occurs as an impurity in commercial benzene and is used as a solvent and in organic syntheses.Физические свойства
Clear, colorless liquid with an aromatic odor resembling benzene. An odor threshold concentration of 0.056 ppbv was reported by Nagata and Takeuchi (1990).Использование
Thiophene is used as a building block of various organic molecules and pharmaceuticals providing functional properties.Определение
ChEBI: Thiophene is a monocyclic heteroarene that is furan in which the oxygen atom is replaced by a sulfur. It has a role as a non-polar solvent. It is a mancude organic heteromonocyclic parent, a member of thiophenes, a monocyclic heteroarene and a volatile organic compound.Методы производства
Thiophene is present in coal tar and is recovered in the benzene distillation fraction (up to about 0.5% of the benzene present). Its removal from benzene is accomplished by mixing with concentrated sulfuric acid, soluble thiophene sulfonic acid being formed. Thiophene gives a characteristic blue coloration with isatin in concentrated sulfuric acid. The basic nomenclature of the thiophene ring system and its derivatives is indicated by the following: the sulfur atom is number 1, positions 2 and 5 are equivalent in the parent ring, as are the 3 and 4 positions.Общее описание
Thiophene appears as a colorless liquid with an unpleasant odor. Insoluble in water and slightly denser than water. Flash point 30 °F. Vapors heavier than air. Irritates the skin, eyes, and mucous membranes. Used to make pharmaceuticals and dyes.Реакции воздуха и воды
Highly flammable. Insoluble in water.Профиль реактивности
Thiophene reacts violently with strong oxidizing agents and concentrated nitric acid causing fire and explosion hazards [Handling Chemicals Safely 1980. p. 899]. A mixture of Thiophene and N-nitrosoacetanilide exploded at 0°C [Ber., 1887, 30, 367].Опасность
Flammable, dangerous fire risk.Угроза здоровью
May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.Пожароопасность
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.Профиль безопасности
Poison by ingestion and intraperitoneal routes. Mildly toxic by inhalation and subcutaneous routes. A very dangerous fire hazard when exposed to heat or flame. Explosive reaction with N-nitrosoacetanilide. Violent or explosive reaction with nitric acid. Incompatible with oxidizing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits highly toxic fumes of SOx.Экологическая судьба
Photolytic. A rate constant 9.70 x 10-12 cm3/molecule?sec was reported for the reaction of thiophene and OH radicals in the atmosphere at room temperature (Atkinson, 1985). Thiophene also reacts with NO3 radicals in the atmosphere at rate constants ranging from 3.2 x 10-14 (Atkinson et al., 1985) to 3.93 x 10-14 cm3/molecule?sec (Atkinson, 1991).Методы очистки
The simplest purification procedure is to dry thiophen with solid KOH, or reflux it with sodium, and fractionally distil it through a glass-helices-packed column. More extensive treatments include an initial wash with aqueous HCl, then water, drying with CaSO4 or KOH, and passage through columns of activated silica gel or alumina. Fawcett and Rasmussen [J Am Chem Soc 67 1705 1945] washed thiophene successively with 7M HCl, 4M NaOH, and distilled water, dried with CaCl2 and fractionally distilled it. *Benzene was removed by fractional crystallisation by partial freezing, and the thiophene was degassed and sealed in Pyrex flasks. [Also a method is described for recovering the thiophene from the *benzene-enriched portion.] [Beilstein 17 H 29, 17 I 17, 17 II 35, 17 III/IV 234, 17/1 V 297.]Тиофен запасные части и сырье
сырьё
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