ЛИТИЙ углекислый

Химические свойства

Lithium carbonate is a white hygroscopic powder.

Физические свойства

White monoclinic crystals; refractive index 1.428; density 2.11 g/cm³; melts at 723°C; decomposes at 1,310°C; low solubility in water (1.54 g/100g) at 0°C; 1.32 g//100g at 20°C), solubility decrease with temperature (0.72g/100g at 100°C); insoluble in acetone and ethanol.

Использование

Lithium carbonate is used as a compound for producing metallic lithium. Lithium carbonate is the result of treating the mineral spodumene with sulfuric acid and then adding calcium carbonate. It is used as an antidepressant.

Показания

Lithium inhibits thyroidal incorporation of I^- into Tg, as well as the secretion of thyroid hormones, but it does not inhibit the activity of the Na⁺-I^- symporter or the accumulation of I^- within the thyroid. Lithium offers no particular advantage over drugs of the thionamide class but may be employed for temporary control of thyrotoxicosis in patients who are allergic to both thionamides and iodide.

Подготовка

Lithium carbonate is prepared by the precipitation of lithium ion by carbonate ion from an aqueous solution. Still another process, which is carried out on a smaller scale, is the reaction of a solution of lithium hydroxide with carbon dioxide gas. Lithium carbonate precipitates and is recovered from the supernatant solution.

Определение

lithium carbonate: A white solid,Li2CO3; r.d. 2.11; m.p. 723°C; decomposesabove 1310°C. It is producedcommercially by treating the ore with sulphuric acid at 250°C andleaching the product to give a solutionof lithium sulphate. The carbonateis then obtained by precipitationwith sodium carbonate solution.Lithium carbonate is used in the preventionand treatment of manicdepressivedisorders. It is also usedindustrially in ceramic glazes.

Общее описание

Lithiumcarbonate (Eskalith, Lithane) and lithium citrate(Cibalith-S) are the salts commercially available in theUnited States.

Профиль реактивности

A base. Decomposed by acids with the evolution of carbon dioxide. Fluorine burns fiercely on contact with Lithium carbonate.

Побочные эффекты

Drowsiness, dizziness, tiredness, increased thirst, increased frequency of urination, weight gain, and mildly shaking hands (fine tremor) may occur. These should go away as your body adjusts to the medication. This medication may increase serotonin and rarely cause a very serious condition called serotonin syndrome/toxicity. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take (see Drug Interactions section). Get medical help right away if you develop some of the following symptoms: fast heartbeat, hallucinations, loss of coordination, severe dizziness, severe nausea/vomiting/diarrhea, twitching muscles, unexplained fever, unusual agitation/restlessness.

Профиль безопасности

Human carcinogenic data. Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Human systemic effects by ingestion: toxic psychosis, tremors, changes in fluid intake, muscle weakness, increased urine volume, nausea or vomiting, allergic dermatitis. Human reproductive effects by ingestion: effects on newborn, including Apgar score changes and other neonatal measures or effects. Human teratogenic effects by ingestion: developmental abnormalities of the cardiovascular system, central nervous system, musculoskeletal and gastrointestinal systems. An experimental teratogen. Experimental reproductive effects. Experimental carcinogen producing leukemia and thyroid tumors. Human mutation data reported. Used in the treatment of manic-depressive psychoses. Incompatible with fluorine. See also LITHIUM COMPOUNDS.

Возможный контакт

Lithium carbonate is used in treatment of manic-depressive psychoses; to make ceramics and porcelain glaze; varnishes, dyes, pharmaceuticals, coating of arc-welding electrodes; battery alloys; nucleonics, luminescent paints; glass ceramics; lubricating greases; in aluminum production

Перевозки

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required

Методы очистки

Crystallise it from water. Its solubility decreases as the temperature is raised. The solubility in H2O is 1.3% at ~10o, and 0.7% at ~100o. [D.nges in Handbook of Preparative Inorganic Chemistry (Ed. Brauer) Academic Press Vol I p 987 1963, Caley & Elving Inorg Synth I 1 1939.]

Несовместимости

The aqueous solution is a strong base. Reacts violently with acids, powdered calcium and fluorine.Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong acids, powdered calcium, fluorine, moisture. Corrodes aluminum, copper, zinc.