4-Хлор-3-метилфенол
- английское имя4-Chloro-3-methylphenol
- CAS №59-50-7
- CBNumberCB5703115
- ФормулаC7H7ClO
- мольный вес142.58
- EINECS200-431-6
- номер MDLMFCD00002323
- файл Mol59-50-7.mol
химическое свойство
| Температура плавления | 63-65 °C (lit.) |
| Температура кипения | 235 °C (lit.) |
| плотность | 1.370 |
| Плотность накопления | 800kg/m3 |
| давление пара | <0.1 hPa (20 °C) |
| показатель преломления | 1.5449 (estimate) |
| Fp | 118 °C |
| температура хранения | Store below +30°C. |
| растворимость | methanol: soluble1g/10 mL, clear, colorless |
| форма | Tablets |
| пка | pKa 9.55(t = 25) (Uncertain) |
| цвет | White |
| РН | 6.5 (1g/l, H2O, 20℃) |
| Растворимость в воде | 4 g/L (20 ºC) |
| Мерк | 14,2133 |
| БРН | 1237629 |
| констант закона Генри | 2.5(x 10-6 atm?m3/mol)at 20 °C (calculated, Mabey et al., 1982) |
| Стабильность | Stable. Incompatible with brass, oxidizing agents, copper, copper alloys. |
| ИнЧИКей | CFKMVGJGLGKFKI-UHFFFAOYSA-N |
| LogP | 3.100 |
| Непрямые добавки, используемые в веществах, контактирующих с пищевыми продуктами | 4-CHLORO-3-METHYLPHENOL |
| FDA 21 CFR | 175.105; 176.200 |
| Справочник по базе данных CAS | 59-50-7(CAS DataBase Reference) |
| Рейтинг продуктов питания EWG | 5 |
| FDA UNII | 36W53O7109 |
| Справочник по химии NIST | Phenol, 4-chloro-3-methyl-(59-50-7) |
| Система регистрации веществ EPA | p-Chloro-m-cresol (59-50-7) |
| UNSPSC Code | 12352104 |
| NACRES | NA.22 |
больше
| Коды опасности | Xn,N,T,F | |||||||||
| Заявления о рисках | 21/22-41-43-50-39/23/24/25-23/24/25-11-38 | |||||||||
| Заявления о безопасности | 26-36/37/39-61-45-36/37-16-7-28 | |||||||||
| РИДАДР | UN 3077 9/PG 3 | |||||||||
| WGK Германия | 2 | |||||||||
| RTECS | GO7100000 | |||||||||
| Температура самовоспламенения | 590 °C | |||||||||
| TSCA | Yes | |||||||||
| Класс опасности | 6.1(a) | |||||||||
| Группа упаковки | II | |||||||||
| кода HS | 29081000 | |||||||||
| Банк данных об опасных веществах | 59-50-7(Hazardous Substances Data) | |||||||||
| Токсичность | LD50 orally in Rabbit: 1830 mg/kg LD50 dermal Rat > 2000 mg/kg | |||||||||
| NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H335：Может вызывать раздражение верхних дыхательных путей.
H317：При контакте с кожей может вызывать аллергическую реакцию.
H314：При попадании на кожу и в глаза вызывает химические ожоги.
H410：Чрезвычайно токсично для водных организмов с долгосрочными последствиями.
H302+H312：Вредно при проглатывании или при попадании на кожу.
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оператор предупредительных мер
P260：Не вдыхать газ/ пары/ пыль/ аэрозоли/ дым/ туман.
P273：Избегать попадания в окружающую среду.
P280：Использовать перчатки/ средства защиты глаз/ лица.
P301+P312：ПРИ ПРОГЛАТЫВАНИИ: Обратиться за медицинской помощью при плохом самочувствии.
P303+P361+P353：ПРИ ПОПАДАНИИ НА КОЖУ (или волосы): Снять/удалить немедленно всю загрязненную одежду. Промыть кожу водой.
P305+P351+P338：ПРИ ПОПАДАНИИ В ГЛАЗА: Осторожно промыть глаза водой в течение нескольких минут. Снять контактные линзы, если Вы ими пользуетесь и если это легко сделать. Продолжить промывание глаз.
4-Хлор-3-метилфенол химические свойства, назначение, производство
Химические свойства
white or pink crystalsФизические свойства
Colorless, white, or pinkish crystals with a slight phenolic odor. On exposure to air it slowly becomes light brown.Использование
4-Chloro-3-methylphenol has been used in paint formulations.Методы производства
Chlorocresol is prepared by the chlorination of m-cresol.Общее описание
A pinkish to white crystalline solid with a phenolic odor. Melting point 64-66°C. Shipped as a solid or in a liquid carrier. Soluble in aqueous base. Toxic by ingestion, inhalation or skin absorption. Used as an external germicide. Used as a preservative in paints and inks.Реакции воздуха и воды
Hygroscopic. Soluble in aqueous base.Профиль реактивности
4-Chloro-3-methylphenolS are incompatible with bases, acid chlorides, acid anhydrides, and oxidizing agents. Corrodes steel, brass, copper and copper alloys .Опасность
Irritant to skin.Угроза здоровью
Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.Пожароопасность
Combustible material: may burn but does not ignite readily. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.Фармацевтические приложения
Chlorocresol is used as an antimicrobial preservative in cosmetics and pharmaceutical formulations. It is generally used in concentrations up to 0.2% in a variety of preparations except those intended for oral administration or that contact mucous membrane. Chlorocresol is effective against bacteria, spores, molds, and yeasts; it is most active in acidic media. Preservative efficacy may be reduced in the presence of some other excipients, particularly nonionic surfactants.Контактные аллергены
Chlorocresol is a biocide used for its disinfectant and preservative properties, in topicals or cutting fluid.Профиль безопасности
Poison by intravenous, subcutaneous, and intraperitoneal routes. Moderately toxic by ingestion. An allergen. Mutation data reported. Incompatible with sodium hydroxide. When heated to decomposition it emits toxic fumes of Cl and phosgene. See also CRESOL and CHLOROPHENOLS.Возможный контакт
Chlorinated phenol fungicide, microbiocide, and germicide used to control bacteria, yeasts, and fungi.Экологическая судьба
Biological. When p-chloro-m-cresol was statically incubated in the dark at 25 °C with yeast extract and settled domestic wastewater inoculum, significant biodegradation with rapid adaptation was observed. At concentrations of 5 and 10 mg/L, 78 and 76% biodegradation, respectively, were observed after 7 d (Tabak et al., 1981).Chemical/Physical. At influent concentrations (pH 3.0) of 1.0, 0.1, 0.01, and 0.001 mg/L, the GAC adsorption capacities were 122, 63, 32, and 17 mg/g, respectively. At pH 5.5 and pH 9.0 at influent concentrations of 1.0, 0.1, 0.01, and 0.001 mg/L, the GAC adsorption capacities were 124, 85, 58, and 40 mg/g and 99, 38, 15, and 5.5 mg/g, respectively (Dobbs and Cohen, 1980).
хранилище
Chlorocresol is stable at room temperature but is volatile in steam. Aqueous solutions may be sterilized by autoclaving. On exposure to air and light, aqueous solutions may become yellow colored. Solutions in oil or glycerin may be sterilized by heating at 1608℃ for 1 hour. The bulk material should be stored in a well-closed container, protected from light, in a cool, dry place.Перевозки
UN2669 Chlorocresols solution, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3437 Chlorocresols solid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.Методы очистки
Crystallise the phenol from pet ether or *C6H6. [Beilstein 6 H 381, 6 I 187, 6 II 355, 6 III 1315, 6 IV 2064.]Несовместимости
Chlorocresols react with boranes, alkalies, aliphatic amines, amides, nitric acid, sulfuric acid. Contact with oxidizing agents may cause a fire and explosion hazard. Heat produces phosgene, hydrogen chloride and chlorine gases. Corrosive to aluminum, copper, tin, and other chemically active metals.Утилизация отходов
A good candidate for rotary kiln incineration at a temperature range of 820 to 1600C and residence times of seconds for liquids and gases, and hours for solids.Регуляторный статус
Included in the FDA Inactive Ingredients Database (topical creams and emulsions). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.In Europe, chlorocresol is approved for use in cosmetics at a maximum concentration of 0.2%; however, it is prohibited for use in products intended to come into contact with mucous membranes. In Japan, use of chlorocresol in cosmetics is restricted to a level of 0.5 g/100 g.
4-Хлор-3-метилфенол запасные части и сырье
4-Хлор-3-метилфенол поставщик
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