Основные атрибуты  химическое свойство Информация о безопасности химические свойства, назначение, производство MSDS запасные части и сырье поставщик Обзор
Амиодарон структурированное изображение

Амиодарон

  • английское имяAmiodarone
  • CAS №1951-25-3
  • CBNumberCB5310616
  • ФормулаC25H29I2NO3
  • мольный вес645.31
  • EINECS217-772-1
  • номер MDLMFCD00242801
  • файл Mol1951-25-3.mol
химическое свойство
Температура плавления 54 - 55°C
Температура кипения 635.1±55.0 °C(Predicted)
плотность 1.5730 (estimate)
температура хранения 2-8°C
растворимость Chloroform (Slightly), Methanol (Slightly)
форма Solid
пка 6.56(at 25℃)
цвет Colourless to Pale Yellow
Растворимость в воде 716.4mg/L(25 ºC)
Стабильность Stable. Incompatible with strong oxidizing agents.
InChI InChI=1S/C25H29I2NO3/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3
ИнЧИКей IYIKLHRQXLHMJQ-UHFFFAOYSA-N
SMILES C(C1C2=CC=CC=C2OC=1CCCC)(C1=CC(I)=C(OCCN(CC)CC)C(I)=C1)=O
Справочник по базе данных CAS 1951-25-3(CAS DataBase Reference)
FDA UNII N3RQ532IUT
Код УВД C01BD01
Система регистрации веществ EPA Methanone, (2-butyl-3-benzofuranyl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]- (1951-25-3)
Заявления об опасности и безопасности
Коды опасности Xn
Заявления о рисках 20/21/22
Заявления о безопасности 36
WGK Германия 3
RTECS OB1361000

рисовальное письмо(GHS)

  • рисовальное письмо(GHS)

    GHS hazard pictograms

  • сигнальный язык

    предупреждение

  • вредная бумага

    H302:Вредно при проглатывании.

  • оператор предупредительных мер

    P264:После работы тщательно вымыть кожу.

    P270:При использовании продукции не курить, не пить, не принимать пищу.

    P301+P312:ПРИ ПРОГЛАТЫВАНИИ: Обратиться за медицинской помощью при плохом самочувствии.

    P501:Удалить содержимое/ контейнер на утвержденных станциях утилизации отходов.

Амиодарон MSDS

Амиодарон химические свойства, назначение, производство

Описание

From the chemical point of view, amiodarone is completely different from other antiarrhythmics. It has two iodide atoms and a diethylaminoethanol group as substituents in the benzoyl part, and overall it is very similar to the structure of thyroxin-like molecules.

Использование

antibacterial

Определение

ChEBI: A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.

Показания

Clinical use of amiodarone is limited because of its high toxicity, which consists of cardiac block, bradycardia, cardiac insufficiency, damaged thyroid gland function, neuropathology, and increased sensitivity to light, all of which significantly limit use of amiodarona, and it is only used in therapy for extremely serious tachyarrhythmias such as reoccurring ventricular fibrillation and hemodynamic unstable ventricular tachycardia, and only under supervision of a physician in a clinical situation.

Биологические функции

Amiodarone (Cordarone) is an iodine-containing benzofuran derivative identified as a class III agent because it predominantly prolongs action potentials. Amiodarone also blocks sodium and calcium channels and is a noncompetitive β-receptor blocker.Amiodarone is effective for the treatment of most arrhythmias. Toxicity associated with amiodarone has led the U. S. Food and Drug Administration (FDA) to recommend that it be reserved for use in patients with life-threatening arrhythmias.

Общее описание

Amiodarone, 2-butyl-3-benzofuranyl-4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone (Cordarone),was introduced as an antianginal agent. It has very pronouncedclass III action and is especially effective in maintainingsinus rhythm in patients who have been treated bydirect current shock for atrial fibrillation. Like class IIIantiarrhythmic drugs, amiodarone lengthens the effective refractoryperiod by prolonging the action potential duration inall myocardial tissues. Amiodarone is eliminated very slowlyfrom the body, with a half-life of about 25 to 30 days after oraldoses. Although the drug has a broad spectrum of antiarrhythmicactivity, its main limitation is a slow onset of action.Drug action may not be initiated for several days, and thepeak effect may not be obtained for several weeks.

Механизм действия

Amiodarone’s antiarrhythmic action is connected to its ability to block K, Na, and Ca2 channels while noncompetitively blocking α- and β-adrenergic receptors of the heart, thus prolonging the action potential and effective refractive period of atrial cells, atrioventricular junctions, and ventricles of the heart, which is accompanied by decreased automatism of sinus node and slowing of atrioventricular conductivity.

Клиническое использование

Amiodarone has adverse effects involving many differentorgan systems. It also inhibits metabolism of drugscleared by oxidative microsomal enzymes. It contains iodinein its molecular structure and, as a result, has an effecton thyroid hormones. Hypothyroidism occurs in up to 11%of patients receiving amiodarone. The principal effect isthe inhibition of peripheral conversion of T4 to T3. Serumreverse T3 (rT3) is increased as a function of the dose as wellas the length of amiodarone therapy. As a result, rT3 levelshave been used as a guide for judging adequacy of amiodaronetherapy and predicting toxicity.

Профиль безопасности

Poison by intravenous and intraperitoneal routes. Human systemic effects by ingestion: photosensitivity of the skin. A flammable liquid. When heated to decomposition it emits very toxic fumes of Iand NO,. A coronary vasoddator

взаимодействия лекарств

Amiodarone increases the hypoprothrombinemic response to warfarin (an oral anticoagulant) by reducing its metabolism. Patients receiving digoxin may undergo an increase in serum digoxin concentrations when amiodarone is added to the treatment regimen. Amiodarone interferes with hepatic and renal elimination of flecainide, phenytoin, and quinidine.

Меры предосторожности

Amiodarone is contraindicated in patients with sick sinus syndrome and may cause severe bradycardia and secondand third-degree atrioventricular block. Amiodarone crosses the placenta and will affect the fetus, as evidenced by bradycardia and thyroid abnormalities. The drug is secreted in breast milk.

Амиодарон поставщик

поставщик телефон страна номенклатура продукции благоприятные условия
+undefined-86-1906231316-9
+undefined86-19062313169
China 709 58
+86 13288715578
+8613288715578
China 12835 58
+8617732866630 China 18154 58
+86-17331933971
+86-17331933971
China 2472 58
+86-0086-57187702781
+8613675893055
China 295 58
+86-0371-55170693
+86-19937530512
China 21636 55
18871490254 CHINA 28172 58
+86-0371-86658258
+8613203830695
China 29814 58
+1-781-999-5354
+1-00000000000
United States 32077 58
+86-0551-65418671
+8618949823763
China 34553 58