Нефазодон

Химические свойства

Crystalline Solid

Использование

A selective serotonin 5-HT2 receptor antagonist. An antidepressant

Биологические функции

Although nefazodone (Serzone) is structurally related to trazodone, it is less sedating. It does not block α₁- adrenoreceptors, and its use is not associated with priapism. Nefazodone inhibits the neuronal reuptake of serotonin and blocks 5HT2A receptors. Its short half-life requires dosing twice a day. Nefazodone is not associated with weight gain or sexual dysfunction. It inhibits the cytochrome P450 3A4 isoenzyme that is responsible for 50% of known oxidative metabolism, and therefore, nefazodone can elevate levels of drugs dependent on this pathway for metabolism.