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Прогестерон
- английское имяProgesterone
- CAS №57-83-0
- CBNumberCB4224484
- ФормулаC21H30O2
- мольный вес314.46
- EINECS200-350-6
- номер MDLMFCD00003658
- файл Mol57-83-0.mol
Температура плавления | 128-132 °C (lit.) |
Температура кипения | 394.13°C (rough estimate) |
альфа | 186 º (c=1, ethanol) |
плотность | d23 1.166; d20 1.171 |
показатель преломления | 182 ° (C=2, Dioxane) |
Fp | 2℃ |
температура хранения | room temp |
растворимость | H2O: 25 mg/mL, may be clear to slightly hazy |
форма | powder |
цвет | Yellow to yellow-brown |
Растворимость в воде | <0.1 g/100 mL at 19 ºC |
Мерк | 7773 |
БРН | 1915950 |
BCS Class | 4 |
Стабильность | Stable. Incompatible with strong oxidizing agents. |
ИнЧИКей | RJKFOVLPORLFTN-LEKSSAKUSA-N |
LogP | 3.870 |
Справочник по базе данных CAS | 57-83-0(CAS DataBase Reference) |
FDA 21 CFR | 556.540 |
Рейтинг продуктов питания EWG | 4-7 |
Словарь онкологических терминов NCI | progesterone; progestin |
FDA UNII | 4G7DS2Q64Y |
Словарь наркотиков NCI | Lutex |
Код УВД | G03DA04 |
Предложение 65 Список | Progesterone |
Справочник по химии NIST | Progesterone(57-83-0) |
Система регистрации веществ EPA | Progesterone (57-83-0) |
Коды опасности | Xn,T,F | |||||||||
Заявления о рисках | 40-45-62-36-20/21/22-11 | |||||||||
Заявления о безопасности | 36/37-45-53-16 | |||||||||
РИДАДР | UN 1648 3 / PGII | |||||||||
WGK Германия | 3 | |||||||||
RTECS | TW0175000 | |||||||||
кода HS | 29372390 | |||||||||
Банк данных об опасных веществах | 57-83-0(Hazardous Substances Data) | |||||||||
Токсичность | LD50 intraperitoneal in rat: 327mg/kg | |||||||||
NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H351:Предполагается, что данное вещество вызывает раковые заболевания.
H362:Может причинить вред детям, находящимся на грудном вскармливании.
H360FD:Может отрицательно повлиять на способность к деторождению. Может отрицательно повлиять на неродившегося ребенка.
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оператор предупредительных мер
P202:Перед использованием ознакомиться с инструкциями по технике безопасности.
P260:Не вдыхать газ/ пары/ пыль/ аэрозоли/ дым/ туман.
P263:Избегать контакта в период беременности и грудного вскармливания.
P264:После работы тщательно вымыть кожу.
P270:При использовании продукции не курить, не пить, не принимать пищу.
P308+P313:ПРИ подозрении на возможность воздействия обратиться за медицинской помощью.
Прогестерон химические свойства, назначение, производство
Описание
Progesterone, along with pregnenolone, is the biosynthetic precursor of all other steroid hormones. Progesterone is synthesized from cholesterol by the sequential action of desmolase in the mitochondria, which produces pregnenolone, followed by Δ4,5-Химические свойства
White powder. Melting point 121°C. Stable in air. Insoluble in water. A female sex hormone. Low toxicity.Вхождение
Colchicum luteum also yields this alkaloid.Определение
ChEBI: Progesterone is a C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species. It has a role as a contraceptive drug, a progestin, a progesterone receptor agonist, a human metabolite and a mouse metabolite. It is a 20-oxo steroid, a 3-oxo-Delta(4) steroid and a C21-steroid hormone. It derives from a hydride of a pregnane.Общее описание
Progesterone, pregn-4-en-3,20-dione, is so rapidly metabolized that it is not particularlyeffective orally, being only one twelfth as active as intramuscularly.An oral formulation of micronized progesterone(Prometrium) is available. Progesterone given intramuscularlycan be very irritating. A vaginal gel containing 4% or8% progesterone offers an alternative dosage form.Progesterone was originally obtained from animal ovariesbut is now prepared synthetically from plant sterol precursors.The discovery of 19-nortestosterones with progesteroneactivity made synthetically modified progestins of tremendoustherapeutic importance.Progesterone (and all other steroid 4-ene-3-ones) is lightsensitive and should be protected from light.
Реакции воздуха и воды
Insoluble in water.Профиль реактивности
Progesterone is sensitive to light .Опасность
A carcinogen (OSHA).Угроза здоровью
ACUTE/CHRONIC HAZARDS: Progesterone may be absorbed through the skin.Пожароопасность
Flash point data for Progesterone are not available; however, Progesterone is probably combustible.Биологическая активность
Endogenous progesterone receptor (PR) agonist (EC 50 = 0.5 nM).Побочные эффекты
Common side effects of oral Progesterone include: chest pain, chills, cold or flu-like symptoms; cough or hoarseness; fever, and problems with urination. Rare side effects include: clear or bloody discharge; dimpling of the breast skin, lumps in the breast or armpit; persistent crusting or flaking; redness or swelling of the breast; and sores on the breast skin that do not heal. Other side effects that may occur are: abdominal or stomach pain; constipation, difficulty breathing, dizziness, fast, strong, or irregular heartbeat or pulse; headache, measles, indigestion, itching, joint pain, stiffness, or swelling; rash.Профиль безопасности
NTP 10th Report on Carcinogens. IARC Cancer Review: Animal Lirmted Evidence IMEMDT 21,491,79; Animal Sufficient Evidence IMEMDT 6,135,74. EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory. SAFETY PROFILE: Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by intravenous and intraperitoneal routes. Human teratogenic effects by ingestion and parenteral routes: developmental abnormalities of the urogenital system. Human male reproductive effects by intramuscular route: changes in spermatogenesis, the prostate, seminal vesicle, Cowper's gland and accessory glands, impotence, and breast development. Human female reproductive effects by ingestion, parenteral, and intravaginal routes: ferthty changes; menstrual cycle changes and disorders; uterus, cervix, and vagina changes. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.Канцерогенность
Progesterone is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.Методы очистки
The form crystallises from EtOH with m 127-131o. The -form crystallises from pet ether or aqueous pet ether/aqueous Et2O with m 119-120o or 121o. It also crystallises from Et2O, Me2CO/EtOAc, MeOH, aqueous Et2O, aqueous MeOH, wet pet ether, Et2O/pet ether, pet ether/*C6H6, Et2O/pentane and isopropyl ether. The is at 240nm with log 4.25 (EtOH). [Wintersteiner & Allen J Biol Chem 107 max 321 1934, Beilstein 7 III 3648, 7 IV 2395.]Прогестерон запасные части и сырье
сырьё
запасной предмет
- 17-Hydroxy-16-methylpregna-5,9(11)-diene-3,20-dione 3,20-diethyleneketal
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- 9-Bromo-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione-21-acetate
- 16-дегидропрогестерон
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