Авасимиб
- английское имяAvasimibe
- CAS №166518-60-1
- CBNumberCB3854950
- ФормулаC29H43NO4S
- мольный вес501.72
- EINECS1592732-453-0
- номер MDLMFCD00934956
- файл Mol166518-60-1.mol
химическое свойство
| Температура плавления | 178-180° (Lee); mp 169.5-170.4° (Dozeman) |
| плотность | 1.072±0.06 g/cm3(Predicted) |
| температура хранения | room temp |
| растворимость | DMSO: ≥40mg/mL |
| форма | powder |
| пка | 1.97±0.70(Predicted) |
| цвет | white to tan |
| ИнЧИКей | PTQXTEKSNBVPQJ-UHFFFAOYSA-N |
| FDA UNII | 28LQ20T5RC |
| UNSPSC Code | 12352200 |
Авасимиб химические свойства, назначение, производство
Использование
Avasimibe is a selective inhibitor of Cholesterol Acyltransferase 1 and CYP2C9. Avasimibe is known to induce apoptosis of glioma cell lines as a model of glioblastoma.Биохимия/физиол Действия
Avasimibe (CI-1011) is an orally bioavailable Acyl-CoA:Cholesterol O-Acyltransferase (ACAT) inhibitor. It was originally developed as an antilepic drug, and was shown to significantly reduce plasma total triglyceride and VLDL-cholesterol, but later clinical trials were disappointing. ACAT has also been investigated as a potential therapeutic target for Alzheimer′s disease. Recent studies have looked at the effects of avasimibe in reducing amyloid pathology by limiting generation and increasing clearance of diffusible amyloid-beta (Abeta).Авасимиб поставщик
| поставщик | телефон | страна | номенклатура продукции | благоприятные условия |
|---|---|---|---|---|
| +86-（0）57185586718 +86-13336195806 |
China | 29792 | 60 | |
| +undefined-21-51877795 | China | 32965 | 60 | |
| 0086-13720134139 | CHINA | 965 | 58 | |
| 18871490254 | CHINA | 28172 | 58 | |
| 8485655694 | United States | 63687 | 58 | |
| 13480692018 | CHINA | 954 | 58 | |
| +86-0371-86658258 +8613203830695 |
China | 29809 | 58 | |
| +1-781-999-5354 +1-00000000000 |
United States | 32161 | 58 | |
| 86-571-88216897,88216896 13588875226 |
CHINA | 6312 | 58 | |
| +86-29-89586680 +86-15129568250 |
China | 22787 | 58 |