ИЗОПРОПИЛБЕНЗОЛ

Описание

Cumene is a common name for isopropylbenzene, an organic compound. Cumene is a volatile colorless liquid at room temperature with a characteristic sharp, penetrating, aromatic odor. It is insoluble in water but is soluble in alcohol and many other organic solvents. Cumene is structurally a member of the alkyl aromatic family of hydrocarbons, which also includes toluene (methylbenzene) and ethylbenzene.Cumene can be found in crude oil, refined fuels, and is a part of processed highoctane gasoline.
Cumene is manufactured by reacting benzene with propylene at elevated temperature and pressure in the presence of a catalyst. It is considered an environmental pollutant because it is a natural component of petroleum and is present in tobacco smoke. Cumene vapor can be absorbed by the respiratory tract. Sufficiently high levels of exposure to cumene causes central nervous system (CNS) depression leading to death, internal bleeding of numerous organs, as well as irritation of the eyes and respiratory system, skin, and mucous membranes. Cumene is a high production volume chemical.

Химические свойства

cumene is oxidized to its hydroperoxide, which is used to produce propene oxide. The alcohol produced is subsequently converted back to cumene over a copper-chromium oxide catalyst to be reused in the process. The advantage of this process is that cumene is easier to hydroperoxidate (more stable).

Физические свойства

Colorless liquid with an aromatic odor. Experimentally determined detection and recognition odor threshold concentrations were 40 μg/m³ (8 ppb_v) and 230 μg/m³ (47 ppb_v), respectively (Hellman and Small, 1974). The taste threshold concentration in water is 60 ppb (Young et al., 1996).

Использование

Around 98% of cumene is used in the production of phenol and its coproduct, acetone, using cumene hydroperoxide as chemical intermediate. However, the demand for cumene is largely dependent on the performance of phenol’s derivatives, which have resulted in healthy growth rates in demand for cumene. It is also used as a starting material in the production of acetophenone, α-methylstyrene, diisopropylbenzene, and dicumylperoxide. Cumene is used as a thinner for paints, lacquers, and enamels. It is also used in the manufacture of acetophenone, methylstyrene, and other chemicals commonly found in home cleaning products. Minor uses of cumene include as a constituent of some petroleum-based solvents, such as naphtha; in gasoline blending diesel fuel and highoctane aviation fuel; and as a raw material for peroxides and oxidation catalysts such as polymerization catalysts for acrylic and polyester-type resins. It is also a good solvent for fats and resins and has been suggested as a replacement for benzene in many of its industrial applications.

Общее описание

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Реакции воздуха и воды

Flammable. Insoluble in water.

Профиль реактивности

Mixing CUMENE in equal molar portions with any of the following substances in a closed container caused the temperature and pressure to increase: chlorosulfonic acid, nitric acid, oleum, NFPA 1991.

Опасность

Toxic by ingestion, inhalation, and skin absorption; a narcotic. Moderate fire risk. Eye, skin, and upper respiratory tract irritant, and central nervous system impairment. Possible carcinogen.

Угроза здоровью

Narcotic action with long-lasting effects; depressant to central nervous system. Acute (short-term) inhalation exposure to cumene may cause headaches, dizziness, drowsiness, slight incoordination, and unconsciousness in humans. Cumene has a potent central nervous system (CNS) depressant action characterized by a slow induction period and long duration of narcotic effects in animals. Cumene is a skin and eye irritant. No information is available on the chronic (long-term), reproductive, developmental, or carcinogenic effects of cumene in humans. Animal studies have reported increased liver, kidney, and adrenal weights from inhalation exposure to cumene. EPA has classified cumene as a Group D, not classifiable as to human carcinogenicity.

Пожароопасность

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Химическая реактивность

Reactivity with Water: No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Профиль безопасности

Moderately toxic by ingestion. Mdly toxic by inhalation and skincontact. Human systemic effects by inhalation: an antipsychotic, unspecified changes in the sense of smell and respiratory system. An eye and skin irritant. Potential narcotic action. Central nervous system depressant. There is no apparent difference between the toxicity of natural cumene and that derived from petroleum. See also BENZENE and TOLUENE. Flammable liquid when exposed to heat or flame; can react with oxidizing materials. Violent reaction with HNO3, oleum, chlorosulfonic acid. To fight fKe, use foam, CO2, dry chemical.

Возможный контакт

Cumene is used primarily in the manufacture acetone and phenol which are widely used as solvents for paints, laquers, and varnishes and to make plastics. Cumene is used in gasoline blending and as a high-octane gasoline component. It is also found as a component in tobacco smoke.

Канцерогенность

Cumene was not a developmental toxicant in either rats or rabbits after exposure to levels (1200ppm and 2300ppm, respectively) associated with maternal toxicity.9 Most genotoxic tests with cumene have been negative.
The LD50 for penetration of rabbit skin was 12.3 ml/kg after 14 days.4 Contact of the liquid with the skin causes erythema and irritation. 11 Eye contamination may produce conjunctival irritation.
It generally is agreed that cumene has no damaging effect on the hematopoietic system, despite its chemical similarity to benzene.5 Furthermore, cumene is not anticipated to be a significant carcinogenic hazard because it is metabolically similar to toluene, a substance that showed no carcinogenic activity in 2-year inhalation studies.

Перевозки

UN1918 Cumene, Hazard Class: 3; Labels: 3-Flammable liquid

Несовместимости

Vapor may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, 942 Cumene fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Air contact forms cumene hydroperoxide. Attacks rubber. May accumulate static electrical charges, and may cause ignition of its vapors.

Утилизация отходов

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.