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Натрий ацетат тригидрат
- английское имяSodium acetate trihydrate
- CAS №6131-90-4
- CBNumberCB3410262
- ФормулаC2H9NaO5
- мольный вес136.08
- EINECS612-115-9
- номер MDLMFCD00071557
- файл Mol6131-90-4.mol
химическое свойство
Температура плавления | 58 °C |
Температура кипения | >400°C |
плотность | 1,45 g/cm3 |
Fp | >250°C |
температура хранения | Store at +5°C to +30°C. |
растворимость | H2O: 3 M at 20 °C, clear, colorless |
форма | Solid |
цвет | White |
Запах | Slight acetic acid |
Водородный показатель | 8.5 - 10 at 408 g/l at 25 °C |
РН | 7.5-9.0 (25℃, 50mg/mL in H2O) |
пка | 4.76 (acetic acid)(at 25℃) |
Растворимость в воде | 762 g/L (20 ºC) |
λмакс | λ: 260 nm Amax: ≤0.01 λ: 280 nm Amax: ≤0.01 |
Мерк | 14,8571 |
БРН | 3732037 |
Стабильность | Stable. Incompatible with strong oxidizing agents, halogens. |
ИнЧИКей | AYRVGWHSXIMRAB-UHFFFAOYSA-M |
LogP | -0.285 (est) |
Справочник по базе данных CAS | 6131-90-4(CAS DataBase Reference) |
FDA UNII | 4550K0SC9B |
Справочник по химии NIST | Sodium acetate trihydrate(6131-90-4) |
Система регистрации веществ EPA | Acetic acid, sodium salt, trihydrate (6131-90-4) |
больше
Коды опасности | Xi | |||||||||
Заявления о рисках | 36/37/38 | |||||||||
Заявления о безопасности | 24/25-36-26 | |||||||||
WGK Германия | 1 | |||||||||
RTECS | AJ4580000 | |||||||||
Температура самовоспламенения | 607 °C | |||||||||
TSCA | Yes | |||||||||
кода HS | 29152200 | |||||||||
Токсичность | LD50 orally in Rabbit: 3530 mg/kg LD50 dermal Rabbit > 10000 mg/kg | |||||||||
NFPA 704: |
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Натрий ацетат тригидрат химические свойства, назначение, производство
Химические свойства
Sodium acetate trihydrate is the trihydrate sodium salt oaf acetic acid. It is a colorless, odorless crystals that can be weathered in the air. Soluble in water and ether, pH of 0.1M aqueous solution is 8.9. moderately soluble in ethanol, 5.3 g/100mL. Anhydrous Sodium acetate occurs as colorless, transparent crystals or a granular crystalline powder with a slight acetic acid odor.Использование
Sodium acetate trihydrate is used in various applications. It is used as a buffer of a pH range in between to 4.0 to 6.0. It is also used in the purification and precipitation of nucleic acids and in protein crystallization. It is used as a mordant dyeing, as a pickling agent in chrome tanning, as a neutralizer in waste streams containing sulfuric acid, in the textile industry and as a photoresist while using aniline dyes. It plays an important role to retard vulcanization of chloroprene in synthetic rubber production. It is a precursor to prepare ester from alkyl halide. Other applications are in photography, as an additive to food, in purification of glucose, in preservation of meat, in tanning, and as a dehydrating agent. In analytical chemistry it is used to prepare buffer solution.Подготовка
Sodium acetate is prepared by reacting sodium hydroxide or sodium carbonate with acetic acid in aqueous solution. The solution is evaporated to obtain hydrated crystals of sodium acetate.NaOH + CH3COOH → CH3COONa + H2O
Na2CO3 + CH3COOH → 2CH3COONa + CO2 + H2O
Общее описание
Sodium acetate trihydrate can be obtained from the crystallization of sodium acetate in water. On heating at 75°C, it melts, while on heating above 120°C it loses water of crystallization and gets converted into anhydrous form. The hyperfine proton and 13C splittings have been evaluated by recording ESR spectra of its irradiated single crystals. ESR studies suggested the existence of trapped methyl radicals. Its crystals are monoclinic and its crystal structure has been investigated by photographic methods. Unit cell parameters were evaluated.Фармацевтические приложения
Sodium acetate is used as part of a buffer system when combined with acetic acid in various intramuscular, intravenous, topical, ophthalmic, nasal, oral, otic, and subcutaneous formulations. It may be used to reduce the bitterness of oral pharmaceuticals. It can be used to enhance the antimicrobial properties of formulations; it has been shown to inhibit the growth of S. aureus and E. coli, but not C. albicans in protein hydrolysate solutions. It is widely used in the food industry as a preservative. Sodium acetate has also been used therapeutically for the treatment of metabolic acidosis in premature infants, and in hemodialysis solutions.Безопасность
Sodium acetate is widely used in cosmetics, foods, and pharmaceutical formulations, and is generally regarded as a nontoxic and nonirritant material.A short-term feeding study in chickens with a diet supplemented with 5.44% sodium acetate showed reduced growth rates that were attributed to the sodium content.(9) Sodium acetate is poisonous if injected intravenously, is moderately toxic by ingestion, and is an irritant to the skin and eyes.
LD50 (rat, oral): 3.53 g/kg
LD50 (mouse, IV): 0.38 g/kg
LD50 (mouse, SC): 8.0 g/kg
хранилище
Sodium acetate should be stored in airtight containers.Несовместимости
Sodium acetate reacts with acidic and basic components. It will react violently with fluorine, potassium nitrate, and diketene.Регуляторный статус
GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (injections, nasal, otic, ophthalmic, and oral preparations).использованная литература
[1] http://www.europlat.org[2] http://www.rxlist.com/sodium-acetate-drug.htm
[3] http://cosmetics.specialchem.com
[4] http://cecri.csircentral.net/2710/1/036-96.pdf
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Натрий ацетат тригидрат поставщик
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