Дигидрата ацетата цинка

Химические свойства

Zinc acetate dihydrate Zn(C2H3O2)•2H2O is a Colourless or white efflorescent crystals; faint acetic acid odor; astringent taste; monoclinic crystals; density 1.735 g/cm3; loses water at 100°C; decomposes at 237°C; readily dissolves in water, 43g/100 mL at 20°C; soluble in alcohol.

Использование

Zinc acetate dihydrate is used in the preparation of layered Zn-arylphosphonates with potential application in sorption, ion exchange or catalysis and zinc sulfide nanoparticles coated on silica particles. It is used in dietary and medical applications. It is also used as lozenges for treating the common cold. It is used as a seeding material to grow zinc oxide nanorods on the microfibers of polyethylene terephthalate fabric. In addition, it finds application as wood preservation, production of other zinc salts, ethylene acetate manufacture, and an analytical reagent in various industries. As a plating inhibitor, it is used in nuclear power plant.

Методы производства

Zinc acetate is synthesized by reacting zinc oxide with glacial acetic acid, with subsequent crystallization, separation by centrifugation, and drying and milling of the crystals. No organic solvents are used during the synthesis.

Общее описание

Structure of zinc acetate dehydrate is monoclinic with unit cell dimensions a=14.50, b=5.32 and c=11.02?.

Фармацевтические приложения

Zinc acetate has been used as an excipient in a variety of pharmaceutical formulations including topical gels, lotions, and solutions, and subcutaneous injections. It has also been investigated for use in an oral controlled-release formulation for water-soluble drugs in combination with sodium alginate and xanthan gum.
Therapeutically, zinc acetate has been used in oral capsules for the treatment of Wilson’s disease. Zinc acetate has also been demonstrated to be effective as a spermicide in vaginal contraceptives.

Безопасность

Zinc acetate is used in topical pharmaceutical formulations and subcutaneous injections, where it is generally regarded as relatively nontoxic and nonirritant when used as an excipient. However, zinc acetate is poisonous by intravenous and intraperitoneal routes; it is also moderately toxic following oral consumption.
LD50 (mouse, IP): 0.108 g/kg
LD50 (mouse, oral): 0.287 g/kg
LD50 (rat, IP): 0.162 g/kg
LD50 (rat, oral): 0.794 g/kg

хранилище

Zinc acetate loses water of hydration above 100℃. Zinc acetate should be stored in an airtight container in a cool, dry, place.

Методы очистки

It crystallises (in poor yield) from hot water or, better, from EtOH. [Beilstein 2 III 193, 2 IV 114.]

Несовместимости

Zinc acetate is incompatible with oxidizing agents, zinc salts, alkalis and their carbonates, oxalates, phosphates, and sulfides.

Регуляторный статус

Included in the FDA Inactive Ingredients Database (SC injections; topical lotions and solutions). Included in medicines licensed in the UK.