Пропил галлат
- английское имяPropyl gallate
- CAS №121-79-9
- CBNumberCB1465703
- ФормулаC10H12O5
- мольный вес212.2
- EINECS204-498-2
- номер MDLMFCD00002196
- файл Mol121-79-9.mol
химическое свойство
| Температура плавления | 146-149 °C(lit.) |
| Температура кипения | 312.03°C (rough estimate) |
| плотность | 1.210 |
| давление пара | 0Pa at 20℃ |
| показатель преломления | 1.5140 (estimate) |
| FEMA | 2947 | PROPYL GALLATE |
| Fp | 187℃ |
| температура хранения | Store below +30°C. |
| растворимость | ethanol: 50 mg/mL |
| форма | powder |
| пка | 8.11(at 25℃) |
| цвет | White to light beige |
| Запах | bland |
| Растворимость в воде | 0.35 g/100 mL (25 ºC) |
| Мерк | 14,7859 |
| БРН | 1877976 |
| ИнЧИКей | ZTHYODDOHIVTJV-UHFFFAOYSA-N |
| LogP | 1.8 |
| FDA 21 CFR | 184.1660; 582.3660; 172.615; 175.125; 175.300; 181.24 |
| Вещества, добавляемые в пищу (ранее EAFUS) | PROPYL GALLATE |
| Специальный комитет по веществам GRAS | Propyl Gallate |
| Справочник по базе данных CAS | 121-79-9(CAS DataBase Reference) |
| Рейтинг продуктов питания EWG | 3 |
| FDA UNII | 8D4SNN7V92 |
| Справочник по химии NIST | Benzoic acid, 3,4,5-trihydroxy-, propyl ester(121-79-9) |
| Система регистрации веществ EPA | Propyl gallate (121-79-9) |
больше
| Коды опасности | Xn | |||||||||
| Заявления о рисках | 22-43-36/37/38 | |||||||||
| Заявления о безопасности | 24-37-36-26 | |||||||||
| WGK Германия | 2 | |||||||||
| RTECS | LW8400000 | |||||||||
| TSCA | Yes | |||||||||
| кода HS | 29182950 | |||||||||
| Банк данных об опасных веществах | 121-79-9(Hazardous Substances Data) | |||||||||
| Токсичность | LD50 in mice, rats, hamsters, rabbits (g/kg): 1.70-3.50, 2.1-7, 2.48, 2.75 orally; LD50 i.p. in rats: 0.38 g/kg (J. Am. Coll. Toxicol.) | |||||||||
| NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H302：Вредно при проглатывании.
H318：При попадании в глаза вызывает необратимые последствия.
H317：При контакте с кожей может вызывать аллергическую реакцию.
H410：Чрезвычайно токсично для водных организмов с долгосрочными последствиями.
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оператор предупредительных мер
P261：Избегать вдыхания пыли/ дыма/ газа/ тумана/ паров/ аэрозолей.
P273：Избегать попадания в окружающую среду.
P280：Использовать перчатки/ средства защиты глаз/ лица.
P301+P312：ПРИ ПРОГЛАТЫВАНИИ: Обратиться за медицинской помощью при плохом самочувствии.
P302+P352：ПРИ ПОПАДАНИИ НА КОЖУ: Промыть большим количеством воды.
P305+P351+P338：ПРИ ПОПАДАНИИ В ГЛАЗА: Осторожно промыть глаза водой в течение нескольких минут. Снять контактные линзы, если Вы ими пользуетесь и если это легко сделать. Продолжить промывание глаз.
Пропил галлат химические свойства, назначение, производство
Описание
Propyl gallate is an antioxidant with antimicrobial activity. It is hepatoprotective in vitro and in vivo, preventing CCl4 induced lipoperoxidation and reduction in polysomes in rat liver. Propyl gallate (100 mg/kg, i.p.) increases expression of HIF-1α, EPO, and VEGF mRNA levels and the number of normal neurons in rat brains after 8 minutes of forebrain ischemia. Propyl gallate in combination with potassium sorbate is bactericidal and bacteriostatic against S. aureus strains known to produce enterotoxins in food. Propyl gallate is commonly added to foods to prevent autoxidation and microbial growth.Использование
Propyl Gallate is a known inhibitor of Tyrosinase, a polyphenol oxidase, which is an important enzyme in pigment biosynthesis in various organisms. It has also recently been seen to boost biodiesel li pid biosynthesis in cultures.Подготовка
Produced commercially by the esterification of gallic acid with propyl alcohol followed by distillation to remove the excess alcohol.Общее описание
Fine white to creamy-white crystalline powder. Odorless or with a faint odor. Melting point 150°C. Insoluble in water. Slightly bitter taste.Реакции воздуха и воды
Insoluble in water.Профиль реактивности
Propyl gallate can react with oxidizing agents. Incompatible with strong acids, strong bases and strong reducing agents. Darkens in the presence of iron and iron salts. Contact with metals should be avoided .Опасность
Use in foods restricted to 0.02% of fat con- tent.Пожароопасность
Propyl gallate is combustible.Контактные аллергены
This gallate ester (E 311) is an antioxidant frequently used in the food, cosmetic, and pharmaceutical industries to prevent the oxidation of unsaturated fatty acids into rancid-smelling compounds. It causes cosmetic dermatitis mainly from lipsticks and induced contact dermatitis in a baker, and in a female confectioner, primarily sensitized by her night cream, who fried doughnuts the margarine probably containing gallates.Токсикология
Propyl gallate (n-propyl-3,4,5-trihydroxybenzoate) is used in vegetable oils and butter. When 1.2 or 2.3% propyl gallate was added to feed for rats, loss of weight was observed. This may be due to the rats reluctance to eat food that was contaminated with the bitter taste of propyl gallate. When it was given for 10 to 16 months at the 2 to 3% level, 40% of the rats died within the first month and the remainder showed severe growth inhibition. Autopsies of rats indicated kidney damage resulting from the ingestion of propyl gallate. However, no other animal studies show serious problems and further studies indicated that propyl gallate does not cause serious chronic toxicities.Профиль безопасности
Poison by ingestion and intraperitoneal routes. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Combustible when exposed to heat or flame; can react with oxidizing materials. When heated to decomposition it emits acrid smoke and irritating fumes.Безопасность
Propyl Gallate currently is used as an antioxidant in a reported 167 cosmetic products at maximum concentrations of 0.1%. Propyl Gallate is a generally recognized as safe (GRAS) antioxidant to protect fats, oils, and fat-containing food from rancidity that results from the formation of peroxides.Методы очистки
Crystallise the ester from aqueous EtOH or *C6H6 (m 146-146.5o). [Beilstein 10 III 2078, 10 IV 2003.]Пропил галлат запасные части и сырье
Пропил галлат поставщик
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