Tocopheryl acetate

Химические свойства

Light yellow to yellow clear liquid

Использование

All-rac-alpha-tocopheryl acetate for peak identification may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography.

Общее описание

DL-α-Tocopherol acetate is a stable ester form of vitamin E, widely used in the formulation of cosmetics for the prevention or correction of skin damage.

Опасность

A reproductive hazard.

Контактные аллергены

Tocopherol and tocopheryl acetate are used mainly as antioxidants. Tocopheryl acetate, an ester of tocopherol (vitamin E), can induce allergic contact dermatitis.

Методы очистки

It is a viscous liquid which is purified by distillation under high vacuum under N2 or Ar and stored in sealed ampoules in the dark. It is considerably more stable to light and air than the parent unacetylated vitamin. It is insoluble in H2O but freely soluble in organic solvents. All eight stereoisomers have been synthesised. The commercially pure d-tocopheryl acetate (2R,4'R,8'R) has b 180-200o/0.7mm and [] D 20 +3.9o (c 5, EtOH); see above. [Cohen et al. Helv Chim Acta 64 1158 1981, Beilstein 17/4 V 169.]