5- (1-гидрокси-2-трет-бутиламиноэтил) бензол-1,3-диол
- английское имя5-(1-Hydroxy-2-tert-butylamino-ethyl)benzene-1,3-diol
- CAS №23031-25-6
- CBNumberCB02131227
- ФормулаC12H19NO3
- мольный вес225.28
- EINECS245-385-8
- файл Mol23031-25-6.mol
химическое свойство
| Температура плавления | 119-122° |
| Температура кипения | 366.8°C (rough estimate) |
| плотность | 1.0951 (rough estimate) |
| показатель преломления | 1.4596 (estimate) |
| температура хранения | Refrigerator |
| растворимость | DMSO (Slightly), Methanol (Slightly) |
| форма | Solid |
| пка | pKa 8.70(H2O t = 25 I = 0.01) (Uncertain);10.09(H2O t = 25 I = 0.01) (Uncertain) |
| цвет | White to Off-White |
| Справочник по базе данных CAS | 23031-25-6 |
| FDA UNII | N8ONU3L3PG |
| Код УВД | R03AC03,R03CC03,R03CC53 |
рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
предупреждение
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вредная бумага
H373：Может поражать органы (Нервная система) в результате многократного или продолжительного воздействия при вдыхании.
H361：Предполагается, что данное вещество может отрицательно повлиять на способность к деторождению или на неродившегося ребенка.
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оператор предупредительных мер
P201：Беречь от тепла, горячих поверхностей, искр, открытого огня и других источников воспламенения. Не курить.
P202：Перед использованием ознакомиться с инструкциями по технике безопасности.
P260：Не вдыхать газ/ пары/ пыль/ аэрозоли/ дым/ туман.
P281：Пользоваться надлежащим индивидуальным защитным снаряжением.
P308+P313：ПРИ подозрении на возможность воздействия обратиться за медицинской помощью.
P314：В случае плохого самочувствия обратиться к врачу.
P405：Хранить в недоступном для посторонних месте.
P501：Удалить содержимое/ контейнер на утвержденных станциях утилизации отходов.
5- (1-гидрокси-2-трет-бутиламиноэтил) бензол-1,3-диол химические свойства, назначение, производство
Описание
Terbutaline is a synthetic congener of adrenaline that acts at the β2-receptor causing bronchodilation and tocolytic effects. It was the first β2-selective adrenoreceptor agonist in general clinical use. In 2011, the Food and Drug Administration (FDA) placed a black-boxed warning on terbutaline stating that terbutaline injections should not be given to pregnant women nor should be used to prevent preterm labor or for long-term (greater than 48–72 h) treatment of preterm labor. Oral terbutaline should not be used at all due to its potential for cardiac toxicity and death. Terbutaline is on the World Anti- Doping Agency’s list of prohibited drugs for Olympic athletes (except when a Therapeutic Use Exemption has been granted in advance and when used by inhalation).Использование
Terbutaline is used for preventing and relieving bronchospasms in bronchial asthma, chronic bronchitis, pulmonary emphysema, and other broncho-pulmonary diseases.Показания
Terbutaline (Brethine, Bricanyl) is a relatively specific β2-adrenoceptor agonist. Terbutaline can prevent premature labor, especially in individuals who are more than 20 weeks into gestation and have no indication of ruptured fetal membranes or in whom labor is not far advanced. Its effectiveness in premature labor after 33 weeks of gestation is much less clear. Terbutaline can decrease the frequency, intensity, and duration of uterine contractions through its ability to directly stimulate β2-adrenoceptors. While it appears to be especially selective for β2-receptor activation, terbutaline does have some β1 activity as well.Определение
ChEBI: A member of the class of phenylethanolamines that is catechol substuted at position 5 by a 2-(tert-butylamino)-1-hydroxyethyl group.Механизм действия
Terbutaline is a synthetic sympathomimetic amine. It is one of the most selective direct–acting stimulants of β2-adrenoreceptors. It stimulates smooth muscle β2-adrenoreceptors in the bronchi, relaxing them and relatively minutely acting on the β1—receptors of the heart.Клиническое использование
Terbutaline should be initially used only in an appropriate hospital setting where any obstetric complications can be readily addressed. After initial administration, it can be used in the outpatient setting. Concomitant use of β2-adrenergic agonists and corticosteroids have additional diabetic effects and may rarely lead to pulmonary edema.The combination of β2- adrenergic agonists and magnesium sulfate can cause cardiac disturbances, while coadministration of terbutaline with other sympathomimetics can lead to the potentiation of the actions of the latter drugs.Побочные эффекты
Terbutaline is frequently used in the management of premature labor, although it has not been marketed for such use. Its effectiveness, side effects, precautions, and contraindications are similar to those of all β2-adrenergic agonists. Terbutaline can cause tachycardia, hypotension, hyperglycemia, and hypokalemia. It can be given orally in addition to subcutaneous or intravenous administration.Экологическая судьба
Terbutaline is administered as the sulfate. It is a white to graywhite, crystalline powder; nearly odorless or with the faint odor of acetic acid. Terbutaline has a slightly bitter taste. It has a melting point of 247°C. Terbutaline sulfate is soluble at 1 g per 1.5 ml water or 250 ml of ethanol. It is soluble in 0.1 N hydrochloric acid, slightly soluble in methanol, and insoluble in chloroform. While terbutaline is stable under normal conditions as a solid, it is unstable in light. Terbutaline is degraded through oxidative processes; this is enhanced in the presence of trace levels of metals and in the presence of oxygen.No information is currently available on breakdown in soil, groundwater, or surface water.
5- (1-гидрокси-2-трет-бутиламиноэтил) бензол-1,3-диол запасные части и сырье
5- (1-гидрокси-2-трет-бутиламиноэтил) бензол-1,3-диол поставщик
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