N-[2-[[[4-(2,2-Dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-(S)-glycine monosodium salt
- русский язык имя
- английское имяN-[2-[[[4-(2,2-Dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-(S)-glycine monosodium salt
- CAS №150374-95-1
- CBNumberCB02131171
- ФормулаC20H21N2NaO7S
- мольный вес456.44
- файл Mol150374-95-1.mol
химическое свойство
| Температура плавления | 104-108 °C(Solv: water (7732-18-5)) |
| температура хранения | Desiccate at RT |
| растворимость | DMSO (Slightly), Methanol (Slightly) |
| форма | Solid |
| цвет | White to Off-White |
| FDA UNII | 0CLL4232KD |
N-[2-[[[4-(2,2-Dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-(S)-glycine monosodium salt химические свойства, назначение, производство
Использование
Treatment of acute lung injury; acute respiratory distress syndrome (elastase inhibitor).Биологическая активность
Selective leukocyte elastase inhibitor (IC 50 = 44 nM) that displays no activity at a range of other proteases. Inhibits NF- κ B activation and LTB 4 -induced neutrophil transmigration in vitro . Significantly attenuates ischemia-induced spinal cord injury, decreases serum cytokine levels and reduces acute inflammatory lung injury in vivo .N-[2-[[[4-(2,2-Dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-(S)-glycine monosodium salt поставщик
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N-[2-[[[4-(2,2-Dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-(S)-glycine monosodium salt Обзор)
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