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Гидрохлорид доксорубицина
- английское имяDoxorubicin hydrochloride
- CAS №25316-40-9
- CBNumberCB0110633
- ФормулаC27H29NO11.ClH
- мольный вес579.98
- EINECS246-818-3
- номер MDLMFCD00077757
- файл Mol25316-40-9.mol
Температура плавления | 216 °C (dec.)(lit.) |
альфа | D20 +248±2° (c = 0.1 in methanol) |
температура хранения | 2-8°C |
растворимость | Soluble in DMSO at 100 mg/ml; very poorly soluble in ethanol; soluble in water at 10 mg/ml with slight warming. |
пка | pKa 8.25±0.60 (Uncertain);8.43±0.70 (Uncertain);11.9±0.4 (Uncertain);12.95±0.1 (Uncertain);13.8±0.70 (Uncertain) |
форма | solid |
цвет | orange to dark red |
Растворимость в воде | Soluble in water. |
λмакс | 497nm(H2O)(lit.) |
Мерк | 14,3439 |
БРН | 4229251 |
Стабильность | Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months. |
ИнЧИКей | MWWSFMDVAYGXBV-RUELKSSGSA-N |
Справочник по базе данных CAS | 25316-40-9(CAS DataBase Reference) |
Словарь онкологических терминов NCI | doxorubicin hydrochloride |
FDA UNII | 82F2G7BL4E |
Словарь наркотиков NCI | doxorubicin hydrochloride |
Предложение 65 Список | Doxorubicin Hydrochloride (Adriamycin) |
Система регистрации веществ EPA | Doxorubicin hydrochloride (25316-40-9) |
Коды опасности | T,T+,Xi | |||||||||
Заявления о рисках | 45-22-40-26/27/28-36/38 | |||||||||
Заявления о безопасности | 53-45-36/37/39-22-7/9 | |||||||||
WGK Германия | 3 | |||||||||
RTECS | QI9295900 | |||||||||
F | 10-21 | |||||||||
кода HS | 29419090 | |||||||||
Токсичность | LD50 i.v. in mice: 21.1 mg/kg (Bertazzoli, 1970) | |||||||||
NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H302:Вредно при проглатывании.
H350:Может вызывать раковые заболевания.
H340:Может вызывать генетические дефекты.
H360FD:Может отрицательно повлиять на способность к деторождению. Может отрицательно повлиять на неродившегося ребенка.
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оператор предупредительных мер
P201:Беречь от тепла, горячих поверхностей, искр, открытого огня и других источников воспламенения. Не курить.
P202:Перед использованием ознакомиться с инструкциями по технике безопасности.
P264:После работы тщательно вымыть кожу.
P270:При использовании продукции не курить, не пить, не принимать пищу.
P301+P312:ПРИ ПРОГЛАТЫВАНИИ: Обратиться за медицинской помощью при плохом самочувствии.
P308+P313:ПРИ подозрении на возможность воздействия обратиться за медицинской помощью.
Гидрохлорид доксорубицина химические свойства, назначение, производство
Химические свойства
Doxorubicin is an orange to red cake-like or needle-like crystalline solid. It is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius. Doxorubicin hydrochloride is an orange-red, crystalline, hygroscopic powder that is soluble in water and slightly soluble in methanol.Использование
Doxorubicin hydrochloride (adriamycin hydrochloride) is an antitumour agent that has been formulated as a salt to achieve higher water solubility. While the salt shares the same pharmacological properties as doxorubicin free base, its greater water solubility may offer advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems the free base and salt may behave differently.Биологические функции
The C13 substituent of doxorubicin is hydroxymethyl, which retards the action of cytosolic aldoketoreductase and slows the conversion to the equally active, but chronically cardiotoxic, doxorubicinol.Общее описание
Adriamycin hydrochloride appears as orange-red thin needles. Aqueous solutions yellow-orange at acid pHs, orange-red at neutral pHs, and violet blue over pH 9. Doxorubicin is available as both the conventional dosageform and a liposomal preparation, both of which are administeredby infusion. Doxorubicin HCl powder is available in10-, 20-, 50-, and 150-mg vials and is widely used in treatingvarious cancers, including leukemias, soft and bone tissuesarcomas, Wilms tumor, neuroblastoma, small cell lungcancer, and ovarian and testicular cancer.Реакции воздуха и воды
Water soluble.Профиль реактивности
Amines, like Doxorubicin hydrochloride, are weak chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.Пожароопасность
Doxorubicin hydrochloride is probably combustible.Биологическая активность
Antitumor antibiotic agent that inhibits DNA topoisomerase II. DNA intercalator that inhibits nucleic acid synthesis and induces apoptosis.Механизм действия
Liposomes are taken up selectively into tumor cells, presumably because of their persistence in the bloodstream and enhanced permeability of tumor vascular membranes. In liposomal form, the drug is protected against enzymes that generate cardiotoxic free radicals, although this form of the drug can still induce potentially fatal congestive heart failure. Clinical experience with the liposomal formulation is limited, and few studies comparing the long-term toxicity with that of conventional doxorubicin therapy have been conducted. Therefore, all precautions outlined for the use of doxorubin also are employed when the liposomal formulation is used.Клиническое использование
Doxorubicin is utilized either alone or in combination therapy to treat a wide range of neoplastic disorders, including hematologic cancers and solid tumors in breast, ovary, stomach, bladder, and thyroid gland. A liposomal formulation of doxorubicin is used in the treatment of AIDS-related Kaposi's sarcoma and organoplatinum-resistant ovarian cancer.Возможный контакт
An antibiotic product from streptomyces, used as anticancer drugМетаболизм
This contributes to the longer duration of action compared to analogues that have CH3 at this position (e.g., daunorubicin). Doxorubicin is highly lipophilic and concentrates in the liver, lymph nodes, muscle, bone marrow, fat, and skin. Elimination is triphasic, and the drug has a terminal half-life of 30 to 40 hours. The majority of an administered dose is excreted in the feces.Перевозки
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.Несовместимости
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxidesУтилизация отходов
It is inappropriate and possibly dangerous to the environment to dispose of expired or waste pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.Гидрохлорид доксорубицина запасные части и сырье
Гидрохлорид доксорубицина поставщик
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