ChemicalBook > Articles Catagory List >Chemical-Reagents >what-is-uses-and-allergy-of-isobornyl-acrylate

What is uses and allergy of Isobornyl acrylate?

Nov 12，2024

Isobornyl acrylate (IBOA) is a acrylate ester monomer with bridged cyclic structures. It is one of important methacrylic ester monomer products on MMA (methyl methacrylate) business.

Article illustration

Uses

Isobornyl acrylate is a monomer in (UV-curing) acrylic resins or adhesives and can be used in these in high concen trations. Two products were found to contain 24% and 61.9% of isobornyl acrylate, but it was not declared as an ingre dient (Henriks-Eckerman and Kanerva 1997; Kanerva et al. 1997). Isobornyl acrylate was detected as a low impurity in average amounts of 500 ng/g in a batch of cocoyl, decyl and dodecyl glucoside. The authors assumed that the substance was released from the plastic containers by the detergents (Foti et al. 2016).

Allergy on the skin

There are only a few publications on clinical findings with isobornyl acrylate, but these clearly show the substance has skin sensitization potential in humans. Isobornyl acrylate is not available as an approved or commercially avail able test preparation and is therefore generally not investigated in patch tests if acrylate sensitization is suspected.

In a local lymph node assay in CBA/Ca mice according to OECD Test Guideline, stimulation indices of 4.07, 14.97 and 22.84, respectively, were determined for isobornyl acrylate (tested in acetone/olive oil (4:1) as 5%, 10% and 25% test preparations) (ECHA 2018), so that an EC3 value (concentration producing a 3-fold increase in lymphocyte prolifer ation) could only be extrapolated. Consequently, isobornyl acrylate had a moderate skin sensitizing potential in this test system.

);