What is Diisopropyl azodicarboxylate?

General Description

Isopropyl azodicarboxylate (Acronym DIAD; foaming agent DIPA) belongs to diisopropyl azo-hydroxy acid salt. At room temperature, it is an orange-red transparent oily liquid with special smell and is soluble in almost all organic solvents and plasticizers.     

It is also insoluble in water but soluble in common plasticizer. It can be well miscible with plastic with good thermal stability. Storage stability: the decomposition substance is colorless, non-toxic, non-pollution, non-blooming and odorless. In the range of 40~120 °C, it can obtain high gas evolution. 

Uses

Isopropyl azodicarboxylate can be used as dye intermediates, pharmaceutical intermediates, organic synthesis reagents, and the foaming agent of the rubber plastics liquid. It can be used for the liquid foaming agent of vinyl resin; used to make light-colored vinyl foam. It has a uniform pore structure with different formulations and processing conditions giving foam of either closed pore or open pore. It can also be used as pharmaceutical intermediates, and organic synthesis reagents.

Uses as a Reagent

Diisopropyl Azodicarboxylate is an azodicarboxylic acid derivative used as a reagent in the production of many organic compounds. Diisopropyl Azodicarboxylate is commonly used as an oxidizer in Mitsun obu reactions and can also serve as a selective deprotectant of N-benzyl groups in the presence of other protecting groups.    

It reacted with dioxaphosphorinanes and iron catalyst to generate rearranged phosphonium ylide products.  Reactant for preparation of:

• Chromenes resembling classical cannabinoids

• MK-3281 inhibitor of the hepatitis C virus NS5B polymerase

• Norbornene-based guanidine-rich polymers as mimcs of cell-penetrating peptides (CPP)

• Analogues of the Pseudomonas aeruginosa quorum-sensing molecule N-(3-Oxododecanoyl)-l-homoserine lactone with immunosuppressive but non-LasR-inducing properties

• Acceptor-donor-acceptor organic dyes for dye-sensitized solar cells

• 1,3-dioxane-2-carboxylic acid derivatives as PPARα/γ dual agonists

• Hydrazinophosphonates and hydrazinobisphosphonates via Mitsunobu and Arbuzov-type multicomponent application of the Morrison-Brunn-Huisgen betaine

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