Uses and effect of Mertansine
Mertansine, also called DM1, is a thiol-containing maytansinoid that for therapeutic purposes is attached to a monoclonal antibody through reaction of the thiol group with a linker structure to create an antibody-drug conjugate.
Mechanism of action
Mertansine is a tubulin inhibitor, meaning that it inhibits the assembly of microtubules by binding to tubulin (at the rhizoxin binding site).
The monoclonal antibody binds specifically to a structure (usually a protein) occurring in a tumour, thus directing mertansine into this tumour. This concept is called targeted therapy.
Uses
The following (experimental) drugs are antibody-drug conjugates (ADC) combining monoclonal antibodies with mertansine as the cytotoxic component. Mertansine is linked via 4-mercaptovaleric acid.
Effect
Mertansine is a thiol-containing derivative of maytansine that is cytotoxic to human epidermoid carcinoma KB and human breast cancer SK-BR-3 cells (IC50 = 1.10 nM for both).Formulations containing mertansine have been studied for the treatment of multiple myeloma and squamous cell carcinoma.
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Lastest Price from Mertansine manufacturers
US $30.00-20.00/BOX2024-03-31
- CAS:
- 139504-50-0
- Min. Order:
- 10BOX
- Purity:
- 99
- Supply Ability:
- 20TONS
US $10.00/KG2021-08-31
- CAS:
- 139504-50-0
- Min. Order:
- 1Kg/Bag
- Purity:
- 99%min
- Supply Ability:
- 20000