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Side effects of Lomefloxacin

Mar 25，2022

Lomefloxacin (Maxaquins, Pfizer) is an older-generation difluoroquinolone that has the chemical formula 1-ethyl-6,8-difluoro-1,4- dihydro-7-(3-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid. Compared with norfloxacin, it has similar spectrum of activity, but has better tissue penetration and, because of a longer half-life, can be given once daily. Lomefloxacin appears to be effective in the treatment of urinary tract and nonpneumococcal respiratory tract infections. With the availability of newer fluoroquinolones that have broader spectrum of activity, similar once-daily dosing, and lower incidence of phototoxicity, its use is now limited. However, it remains available in the Americas (including the USA), South Africa, much of Asia, and Europe (excluding the UK).

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Bioavailability

The absolute bioavailability of lomefloxacin is approximately 95%, with the drug rapidly absorbed after oral administration. Plasma halflife is 6–8 hours and it is approximately 10–15% protein bound. The absorption of lomefloxacin is delayed when the drug is taken at the same time as food, with a delay in the time to peak serum concentrations. However, peak serum concentrations and the amount of lomefloxacin absorbed following either a carbohydrate or high-fat meal are similar to that expected when the drug is taken after an overnight fast.

Excretion

Lomefloxacin undergoes limited metabolism in the liver, to glucuronide and ethylenediamino metabolites. This accounts for less than 10% of a lomefloxacin dose.

Side effects

The rate of adverse reactions associated with lomefloxacin is similar to that associated with other fluoroquinolones. The most commonly reported side-effects include nausea (3.7%), diarrhea (1.4%), photosensitivity (2.4%), headache (3.2%), and dizziness (2.3%). The hierarchy of phototoxic risk among the fluoroquinolones is lomefloxacin, fleroxacinWsparfloxacinWenoxacinWpefloxacinW ciprofloxacin, grepafloxacinWnorfloxacin, ofloxacin, levofloxacin, trovafloxacin, gatifloxacin, moxifloxacin.

The rate of these reactions is higher in elderly patients and in those treated for a longer period of time. Laboratory abnormalities are uncommon, with alterations in hepatic function tests (0.1–1.8%), monocytosis (0.4%), thrombocytopenia (0.1%), decreased hemoglobin (0.1%), and elevated urea (0.2%) most reported. Tendonitis, C. difficile-associated diarrhea, seizures, and peripheral neuropathy have been reported with lomefloxacin .

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