克霉唑

Clotrimazole
23593-75-1

询价 25Kg/Drum 起订

湖北更新日期：2020-11-10

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产品详情:

中文名称：: 克霉唑

英文名称：: Clotrimazole

CAS号：: 23593-75-1

产品类别：: boshan

Clotrimazole CAS 23593-75-1

CP/USP/BP/EP 25kg/DRUM

Clotrimazole structure	Common Name	Clotrimazole
	CAS Number	23593-75-1	Molecular Weight	344.837
	Density	1.1±0.1 g/cm3	Boiling Point	482.3±40.0 °C at 760 mmHg
	Molecular Formula	C22H17ClN2	Melting Point	147-149ºC
	MSDS	ChineseUSA	Flash Point	245.5±27.3 °C
	Symbol	GHS07	Signal Word	Warning

Use of Clotrimazole

Clotrimazole is an imidazole derivative, an antifungal compound and is a CYP (cytochrome P450) inhibitor.Target: Antifungal; CYPClotrimazole (brand name Canesten or Lotrimin) is an antifungal medication commonly used in the treatment of fungal infections (of both humans and other animals) such as vaginal yeast infections, oral thrush, and ringworm. It is also used to treat athlete's foot and jock itch.It is commonly available as an over-the-counter substance in various dosage forms, such as a cream, and also (especially in the case of ear infection) as a combination medicine. It is also available as a troche or throat lozenge (prescription only). For ear infection, it is often applied in liquid form, as ear drops.The antimycotic drug clotrimazole inhibits the function of the gastric H,K-ATPase in a manner similar to that observed for the Na,K-ATPase. Because of the high hydrophobicity of the compound, the interaction between clotrimazole and the ion pump occurs at the membrane domain in the apolar core of the membrane. The enzymatic activity was inhibited with a half-saturating concentration of 5.2 microM. Various partial reactions of the pump cycle were analyzed with the electrochromic styryl dye RH421 that has been widely used to study the transport mechanism of P-type ATPases.

Properties
Articles158
Spectrum

Name	clotrimazole
Synonym	More Synonyms

Description	Clotrimazole is an imidazole derivative, an antifungal compound and is a CYP (cytochrome P450) inhibitor.Target: Antifungal; CYPClotrimazole (brand name Canesten or Lotrimin) is an antifungal medication commonly used in the treatment of fungal infections (of both humans and other animals) such as vaginal yeast infections, oral thrush, and ringworm. It is also used to treat athlete's foot and jock itch.It is commonly available as an over-the-counter substance in various dosage forms, such as a cream, and also (especially in the case of ear infection) as a combination medicine. It is also available as a troche or throat lozenge (prescription only). For ear infection, it is often applied in liquid form, as ear drops.The antimycotic drug clotrimazole inhibits the function of the gastric H,K-ATPase in a manner similar to that observed for the Na,K-ATPase. Because of the high hydrophobicity of the compound, the interaction between clotrimazole and the ion pump occurs at the membrane domain in the apolar core of the membrane. The enzymatic activity was inhibited with a half-saturating concentration of 5.2 microM. Various partial reactions of the pump cycle were analyzed with the electrochromic styryl dye RH421 that has been widely used to study the transport mechanism of P-type ATPases.
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Infection
References	[1]. Sawyer PR, Clotrimazole: a review of its antifungal activity and therapeutic efficacy. Drugs. 1975;9(6):424-47. [2]. Witzke A, Inhibition of the gastric H,K-ATPase by clotrimazole. Biochemistry. 2010 Jun 1;49(21):4524-32.

Description

Related Catalog

Signaling Pathways >> Autophagy >> Autophagy

Signaling Pathways >> Anti-infection >> Fungal

Research Areas >> Infection

References

[1]. Sawyer PR, Clotrimazole: a review of its antifungal activity and therapeutic efficacy. Drugs. 1975;9(6):424-47.

[2]. Witzke A, Inhibition of the gastric H,K-ATPase by clotrimazole. Biochemistry. 2010 Jun 1;49(21):4524-32.

Density	1.1±0.1 g/cm3
Boiling Point	482.3±40.0 °C at 760 mmHg
Melting Point	147-149ºC
Molecular Formula	C22H17ClN2
Molecular Weight	344.837
Flash Point	245.5±27.3 °C
Exact Mass	344.108032
PSA	17.82000
LogP	5.44
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.617
Storage condition	Store at RT.
Water Solubility	Soluble in chloroform, DMSO, DMF and alcohols

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九州通是一家以西药、中药、器械为主要经营产品，以医疗机构、批发企业、零售药店为主要客户对象，并为客户提供信息、物流等各项增值服务的大型企业集团。公司立足于医药健康行业，是中国医药商业领域具有全国性网络的少数几家企业之一，于2010年11月2日在上海证券交易所挂牌上市（股票简称：九州通，证券代码：600998），公司连续多年位列中国医药商业企业第四位，领跑中国民营医药商业企业，2020年位列《财富》（中文版）500强第100位。九州通成立于1999年3月，总部位于湖北省武汉市。截止2020年9月30日，公司注册资本18.78亿元，总资产787.17亿元。实现营业收入803.20亿元，净利润21.41亿元，分别较上年同期增长9.46%和110.23％。扣除非经常性损益后归属于上市公司股东的净利润为12.52亿元，较上年同期增长45.12%。2019年公司实现营业收入994.97亿元，归属于上市公司股东的净利润17.81亿元，分别较上年同期增长14.19%和28.96%。员工两万五千余人。直营和加盟零售连锁药店1074家。

成立日期	(27年)
注册资本	1877663513
员工人数	500人以上
年营业额	￥ 1亿以上
经营模式	贸易,工厂
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