克霉唑；三苯甲咪唑、抗真菌Ⅰ号

Clotrimazol
23593-75-1

询价 25 kg/Drum 起订

浙江更新日期：2019-03-19

宁波市迪盛化学有限公司

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联系人：王***

电话：057***

手机：183***

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产品详情:

中文名称：: 克霉唑；三苯甲咪唑、抗真菌Ⅰ号

英文名称：: Clotrimazol

CAS号：: 23593-75-1

纯度规格：: 99%

产品类别：: raw material

Clotrimazole is an imidazole derivative and an antifungal compound and a CYP (cytochrome P450) inhibitor. Clotrimazole has been shown to block the intermediate-conductance, IK1 channels (Ca2+ activated K+ channels), in cells such as erythrocytes. In vitro studies of various yeast strains have demonstrated susceptibility to clotrimazole. Clotrimazole is an activator of MB67 and an inhibitor of CYP3A4 and CYP51A1.

外观 :Powder

物理状态 :Solid

溶解度 :Soluble in DMSO (25 mM), chloroform (50 mg/ml), DMF, ethyl acetate, ethanol, methanol, and acetone.

保存 :Store at room temperature

熔点 :144-151° C

沸点 :482.30° C at 760 mmHg (Predicted)

密度 :1.14 g/cm3 (Predicted)

折射率 :n20D 1.62 (Predicted)

IC50 :Cytochrome P450 3A4: IC50 = 16 nM (human); Thromboxane-A synthase: IC50 = 14 nM (human); Cytochrome P450 19A1: IC50 = 1.8 nM (human); Plasmodium falciparum: IC50 = 60 nM; Plasmodium falciparum: EC5050 = 338 nM; ATP-dependent molecular chaperone HSP82: EC5050 = 133 nM (Candida albicans (strain WO-1) (Yeast)); Ca2+-activated K+ current: IC50 = 3 µM; Gardos channel: IC50 = 650 nM

Ki 数据 :Dopamine D3 receptor: Ki= 899 nM (human); Muscarinic acetylcholine receptor M4: Ki= 1640 nM (human); Cytochrome P450 17A1: Ki= 81.5 nM (human); Delta opioid receptor: Ki= 1755 nM (human); Serotonin transporter: Ki= 3060 nM (human)

pK值 :pKb: 6.12 (Predicted)

Clotrimazole; API; 1-[(2-Chlorophenyl)diphenylmethyl]imidazole; 1-[(2-chlorophenyl)-diphenylmethyl]imidazole; 1-(2-chlorotrityl)imidazole; 1-(o-Chlorotrityl)imidazole,1-(o-Chl; 1-[(2-chlorophenyl)diphenylmethyl]-1H-imidazole

公司简介

专业从事医药原料、医药中间体及其相关产品进出口贸易的企业。公司成立于2004年，目前我们的业务已经遍布全球超过50个国家，在秘鲁、巴西和哥伦比亚拥有自己的办事处。公司同时拥有自己的股份工厂，生产肾上腺素类和兽药类产品。

成立日期	(18年)
注册资本	伍佰万圆整
员工人数	10-50人
年营业额	￥ 1000万-5000万
经营模式	工厂
主营行业	中间体,医药原料,原料药,激素类,氨基酸及其衍生物