化合物 GSK2334470|T2348|TargetMol

GSK2334470
1227911-45-6

￥198 1mg 起订

￥461 5mg 起订

￥742 10mg 起订

上海更新日期：2024-09-29

TargetMol中国（陶术生物）

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联系人：邵小姐

手机：4008200310 拨打

邮箱：marketing@tsbiochem.com

产品详情:

中文名称：: 化合物 GSK2334470

英文名称：: GSK2334470

CAS号：: 1227911-45-6

品牌：: TargetMol

产地：: 美国

保存条件：: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

纯度规格：: 99.87%

产品类别：: 抑制剂

货号：: T2348

Product Introduction

Bioactivity

Name	GSK2334470
Description	GSK2334470 is a novel PDK1 inhibitor (IC50: ~10 nM, in a cell-free assay), with no inhibitory at other close related AGC-kinases.
Cell Research	GSK2334470 is dissolved in DMSO and diluted with appropriate medium before use. To study the inhibitory effect of GSK2334470 on mTOR-S6K pathway, non-resistant cells and the resistant sublines are treated with GSK2334470 at 5 μM for 1.5 and 12 h in 10 % FBS medium with/without MK-2206 (5 μM)[2].
Kinase Assay	FGFR1-4 Biochemical Assays: FGFR kinase inhibition assays are performed at KM for ATP. Picomolar to low nanomolar concentrations of FGFR proteins are incubated in 1× Kinase Reaction Buffer (KRB) with 1 μM of CSKtide and 50 to 250 of μM ATP at 25°C for 90 minutes in the presence or absence of a dosed concentration series of inhibitor. All reactions are terminated by the addition of Stop buffer, and plates are read on a Caliper EZReader2. IC50 values are fit with a four-parameter log[Inhibitor] versus response model with floating Hill Slope.
In vivo	PDK1抑制剂（PDKi）GSK2334470的效果在新生的BrafV600E::Pten/小鼠中通过系统性给予4-HT进行测试。每周两次给予PDK1，显著抑制色素性病变和随之而来的黑色素瘤的发生，同时显著抑制肺转移（通过H&E染色定量分析约80%）和淋巴结转移（通过S100免疫染色），与Pdk1基因敲除所见表型相似。
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	Ethanol : 83 mg/mL (179.4 mM) DMSO : 83 mg/mL (179.4 mM)
Keywords	GSK-2334470 \| Inhibitor \| GSK 2334470 \| PDK-1 \| inhibit \| GSK2334470
Inhibitors Related	RS1-PDK1 inhibitor \| 6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile \| M77976 \| BX795 \| Osu03012 \| Rabusertib \| Polyphyllin I \| PS 48 \| Dicoumarol \| MP7 \| Dehydroabiethylamine \| Sodium dichloroacetate
Related Compound Libraries	Inhibitor Library \| Bioactive Compound Library \| Anti-Cancer Compound Library \| Bioactive Compounds Library Max \| Anti-Cancer Metabolism Compound Library \| Kinase Inhibitor Library \| Anti-Aging Compound Library \| Highly Selective Inhibitor Library \| Glycolysis Compound Library \| Reprogramming Compound Library

GSK2334470|TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(12年)
注册资本	566.265100万人民币
员工人数	100-500人
年营业额	￥ 1亿以上
经营模式	贸易,工厂,试剂,定制,服务
主营行业	天然产物,生化试剂,分子生物学,分子砌块,生物技术服务