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网站主页 化工产品目录 生物化工 抑制剂 PI3K/Akt/mTOR抑制剂(PI3K/Akt/mTOR) PI3K 抑制剂 HS-173 化合物 HS-173
  • 化合物 HS-173|T2308|TargetMol

化合物 HS-173|T2308|TargetMol

HS-173
1276110-06-5
￥245 1mg 起订
￥343 2mg 起订
￥562 5mg 起订
上海 更新日期：2024-09-29

TargetMol中国（陶术生物）

VIP3年
联系人：邵小姐
手机：4008200310 拨打
邮箱：marketing@tsbiochem.com

产品详情:

中文名称：
化合物 HS-173
英文名称：
HS-173
CAS号：
1276110-06-5
品牌：
TargetMol
产地：
美国
保存条件：
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
纯度规格：
99.64%
产品类别：
抑制剂
货号：
T2308

Product Introduction

Bioactivity

NameHS-173
DescriptionHS-173 is an effective PI3Kα inhibitor (IC50: 0.8 nM).
Cell ResearchCell viability is performed by a MTT assay. Briefly, T47D cells are plated in 96-well plates for 24 h. Then, the medium is removed and cells were treated with either DMSO as a control or various concentrations of inhibitors. The final concentration of DMSO in the medium was ≤0.1% (v/v). After the cells are incubated for 48 h, 20 μL MTT solution (5 mg/mL) is added to each well for another 4 h at 37 °C. The formazan crystals that formed are dissolved in DMSO (100 μL/well) by constant shaking for 5 min. The plate is then read on a microplate reader at 540 nm. Three replicate wells are used for each analysis. The median inhibitory concentration (IC50, defined as the drug concentration at which cell growth is inhibited by 50%) is assessed from the dose?response curves. To assess the effect of compounds on cell proliferation, T47D cells are cultured with compound (0.1?100 μM) for 48 h before MTT analysis.(Only for Reference)
Kinase AssayPI3-Kinase assay: The PI3K assay is performed using the Kinase-Glo Max luminescent kinase assay kit which quantifies the amount of ADP produced by the PI3K reaction. In brief, an active PI3K (100 ng) is preincubated with compound for 5 min in kinase reaction buffer (25 mM MOPS [pH 7.0], 5 mM MgCl2, and 1 mM EGTA) and 10 μg l-α-phosphatidylinositol (PI). Before addition of PI, it is sonicated with sonication buffer (25 mM MOPS [pH 7.0], 1 mM EGTA) in water for 20 min for allowing miscelle formation. Then reaction is started by the addition of 10 μM ATP and ran for 180 min. To terminate kinase reaction, same volume of Kinase-Glo Max buffer is added. After 10 min, the plates are then read on a GloMax plate reader for luminescence detection.
In vitro通过阻断PI3K/Akt信号,HS-173可使体内肝纤维化进程显著减慢.其还可使小鼠体内血管形成减少.
In vivo在体外试验中,通过影响细胞周期分布并激活半胱天冬酶,HS-173可诱导细胞凋亡,并使VEGF诱导的血管生成被阻断。在胰腺癌细胞中,HS-173和索拉非尼联用有协同抗癌效果。在T47D,SK-BR3,和MCF7细胞中,HS-173具有明显的抗增殖这个（IC50：0.6/1.5/7.8 μM）。 HS-173可使癌细胞系(Hep3B和SkBr3)中的PI3K通路被完全抑制。
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 78 mg/mL (184.6 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
KeywordsPI3K | Apoptosis | Phosphoinositide 3-kinase | HS-173 | Inhibitor | inhibit
Inhibitors RelatedLidocaine hydrochloride | Metronidazole | 5-Fluorouracil | Stavudine | Tributyrin | Dextran sulfate sodium salt (MW 4500-5500) | Myricetin | Sorafenib | L-Ascorbic acid | Acetylcysteine | Sodium 4-phenylbutyrate | Kaempferol
Related Compound LibrariesInhibitor Library | Bioactive Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Anti-Aging Compound Library | Stem Cell Differentiation Compound Library | NO PAINS Compound Library | Cancer Cell Differentiation Compound Library | Glycolysis Compound Library | Reprogramming Compound Library
HS173|||HS 173|TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。 凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期 (12年)
注册资本 566.265100万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生化试剂,分子生物学,分子砌块,生物技术服务

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