aladdin 阿拉丁 L413819 LY2584702 对甲苯磺酸盐 1082949-68-5 99%

中文名：LY2584702 对甲苯磺酸盐

英文名：LY2584702 Tosylate

英文别名：LY-2584702 tosylate salt；4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine

纯度：99%

货号：L413819

包装：10mg、50mg、100mg

Cas号：1082949-68-5

存储温度：-20°C储存

产品介绍：

Information

LY2584702 Tosylate LY2584702 Tosylate is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM. Phase 1.

Targets

p70S6K (Cell-free assay) 4 nM

In vitro

In HCT116 colon cancer cells, LY2584702 inhibits phosphorylation of the S6 ribosomal protein (pS6) with IC50 of 0.1-0.24 μM. LY2584702 has significant synergistic effects when combined with EGFR inhibitor erlotinib or with the mTOR inhibitor everolimus.

In vivo

LY2584702 (12.5 mg/kg BID), demonstrates significant antitumor efficacy in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models.

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