aladdin 阿拉丁 Z422183 玉米烯酮 来源于赤霉菌 17924-92-4 10mM in DMSO

中文名：玉米烯酮 来源于赤霉菌

英文名：Zearalenone from Giberella zeae

中文别名：玉米赤霉烯酮

英文别名：ZEARALENONE|17924-92-4|trans-Zearalenone|(-)-Zearalenone|Mycotoxin F2|(S)-Zearalenone|Zenone|(S)-(-)-Zearalenone|(10S)-Zearalenone|C18H22O5|(3S,11E)-14,16-dihydroxy-3-methyl-3,4,5,6,9,10-hexahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione|CHEBI:10106|Com

纯度：10mM in DMSO

货号：Z422183

包装：1ml

Cas号：17924-92-4

存储温度：-80℃储存

产品介绍：

Zearalenone, a phytoestrogenic mycotoxin usually produced by Fusarium species, is shown to be a cytotoxic compound, but alos binds to the estrogen receptor (ER) (IC50 values are 166 and 240 nM for ERβ and ERα respectively) and was found to stimulate the transcriptional activity of both subtypes at concentrations between 1 - 10 nM. This agent has demonstrated the ability to induce apoptosis via activation of mitochondrial release of Cytochrome c, production of reactive oxygen species (ROS), activation of caspase-3 and caspase-8, and induction of endoplasmic reticulum stress. Additional studies suggest that Zearalenone also up-regulates Bax expression and down-regulates Bcl-xL expression in cells, which also contribute to a halt in cell proliferation. The cell growth arrests caused by this mycotoxin seem to take place during the G1 phase of the cell cycle.

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