aladdin 阿拉丁 T408464 盐酸特比萘芬 78628-80-5 10mM in DMSO

中文名：盐酸特比萘芬

英文名：Terbinafine HCl

英文别名：KWD 2019;N-​[(2E)​-​6,​6-​dimethyl-​2-​hepten-​4-​yn-​1-​yl]​-​N-​methyl-​1-​naphthalenemethanami​ne, hydrochloride (1:1)

纯度：10mM in DMSO

货号：T408464

包装：1ml

Cas号：78628-80-5

存储温度：-80℃储存

产品介绍：

Information

Terbinafine HCl Terbinafine HCl (KWD 201) inhibits ergosterol synthesis by inhibiting squalene epoxidase , used as an antifungal drug.
In vitro

Terbinafine (50 μM to 100 μM) inhibits only marginally the metabolism of ethoxycoumarin (CYP1A2), tolbutamide (CYP2C9), or ethynylestradiol, CsA, and cortisol. Terbinafine proves to be a potent inhibitor of the CYP2D6-mediated dextromethorphan O-demethylation and bufuralol 1-hydroxylation with IC50values of 0.2 μM and 0.25 μM, respectively. Terbinafine is highly activ Aspergillus isolates (minimum inhibitory concentration [MIC] 0.01 to 2 mg/mL) with a primary fungicidal action (minimum fungicidal concentration [MFC] 0.02 to 4 mg/mL). Terbinafine inhibits dextromethorphan O-demethylation with an apparent Ki ranging from 28 to 44 nM in human hepatic microsomes and averaging 22.4 nM for the heterologously expressed enzymes. Terbinafine shows a very strong activity in vitro against Penicillium spp., Paecilomyces spp., Trichoderma spp., Acremonium spp. and Arthrographis spp. with GMs <1 mg/L. Terbinafine decreases the levels of phosphorylated extracellular signal-regulated kinase (ERK). Terbinafine might cause a decrease of MEK, which in turn up-regulates p53 through the inhibition of ERK phosphorylation, and finally causes an increase of p21expression and cell-cycle arrest.

In vivo

Cell Data

cell lines：

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Incubation Time：

Powder Purity:≥99%

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