aladdin 阿拉丁 S413720 辛波莫德(BAF312) 1230487-00-9 98%

中文名：辛波莫德(BAF312)

英文名：Siponimod (BAF312)

纯度：Moligand™，≥98%

货号：S413720

Cas号：1230487-00-9

存储温度：-20°C储存,充氩

运输条件：超低温运输

产品介绍：

Information

Siponimod (BAF312) BAF312 (Siponimod) is a next-generation S1P receptor agonist, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors. Phase 3.

Targets

S1P1 receptor ; S1P5 receptor 0.39 nM(EC50); 0.98 nM(EC50)

In vitro

BAF312 (Siponimod) is a potent and selective S1P receptor agonist, with EC50 of 0.39 nM and 0.98 nM for S1P₁ and S1P₅receptors, exhibits >1000-fold selectivity over S1P₂, S1P₃ and S1P₄ receptors. BAF312 (1 h at 1 μM) promotes prominent internalization of S1P1 receptors by 91%.

In vivo

BAF312 effectively suppresses encephalomyelitis (EAE) in rats by internalizing S1P₁ receptors, rendering them insensitive to the egress signal from lymph nodes. BAF312 significantly reduces clinical scores when dosed prophylactically or therapeutically in mice at 0.3 mg/kg.

Cell Research(from reference)

Cell lines：CHO 

Concentrations：~1 μM 

Incubation Time：1 h 

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