微晶纤维素 Avicel PH101 PH102 PH200药用辅料 新品

英文名称

Microcrystalline   Cellulose

英文别名

Avicel PH; Celex;   cellulose-gel; Celphere; Ceolus-KG; crystalline-cellulose; E460; Emcocel;   Ethispheres; Fibrocel; Pharmacel; Tabulose; Vivapur.

化学名称

cellulose

CAS号

9004-34-6

分 子 式

(C₆H₁₀O₅)_n n n≈220

分 子 量

≈36000

结 构 式

分 类

吸附剂;助悬剂;填充剂;片崩解剂

用 途

吸附剂；助悬剂；片剂和胶囊的稀释剂；片剂的崩解剂。微晶纤维素广泛用于药物制剂，主要是在口服片剂和胶囊剂中作为黏合剂或稀释剂，不仅可用于湿法制粒而且可用于直接压片。除了用于黏合剂或稀释剂，微晶纤维素还有一定的润滑和崩解性，故其在片剂的制备中非常有用。

AVICEL PH-101

50

3.0 - 5.0

Conventional grade for wet and dry granulation

AVICEL PH-102

100

3.0 - 5.0

Improves flow in direct compression, dry phase of wet granulation and dry granulation

AVICEL PH-103

50

NMT 3.0

Well suited for moisture sensitive actives

AVICEL PH-105

20

NMT 5.0

Extra-fine particle size, used for direct compression of materials which are coarse or hard to compress

AVICEL PH-112

100

NMT 1.5

Lowest moisture content and is best suited for direct compression of moisture sensitive actives

AVICEL PH-113

50

NMT 2.0

Improves product stability, particularly of formulations using moisture sensitive actives

AVICEL PH-200

200

2.0 - 5.0

Largest particle size, enhances flow in direct compression and dry granulation whilst maintaining high levels of compressibility with minimum weight variation and content uniformity

AVICEL PH-200 LM

200

NMT 1.5

Largest particle size with lowest moisture content, allowing for better flow rate than Avicel PH-112. Improvised grade for direct compression of moisture sensitive actives

AVICEL PH-301

50

3.0 - 5.0

High bulk density grade, for manufacturing of small tablets. Reduces powder stratification and tablet weight variation by allowing efficient mixing

AVICEL PH-302

100

3.0 - 5.0

High bulk density grade with larger particle size, used for production of thin tablets especially in high dose drug formulations. Avoids powder segregation and achieves good flow rates