| Name | Ziprasidone hydrochloride monohydrate |
| Description | Ziprasidone hydrochloride monohydrate (CP 88059) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of the antipsychotic activity. |
| In vitro | Ziprasidone blocked wild-type hERG currents in a voltage- and concentration-dependent manner in stably transfected HEK-293 cells with an IC(50) of 120 nM.Ziprasidone exhibited minimal hERG Ziprasidone significantly increased the time constant of the slow response to hERG current deactivation (-50 mV). ziprasidone is a 5-HT(1A) receptor agonist, as well as a 5-HT(2A), 5-HT(2C) and 5-HT(1B/1D) receptor antagonist. Ziprasidone is similar to the antidepressant promethazine in inhibiting the neuronal uptake of 5-HT and norepinephrine.Ziprasidone exhibits high affinity for human 5-HT receptors and human dopamine D(2) receptors. |
| In vivo | Ziprasidone blocked wild-type hERG currents in a voltage- and concentration-dependent manner in stably transfected HEK-293 cells with an IC(50) of 120 nM.Ziprasidone exhibited minimal hERG Ziprasidone significantly increased the time constant of the slow response to hERG current deactivation (-50 mV). ziprasidone is a 5-HT(1A) receptor agonist, as well as a 5-HT(2A), 5-HT(2C) and 5-HT(1B/1D) receptor antagonist. Ziprasidone is similar to the antidepressant promethazine in inhibiting the neuronal uptake of 5-HT and norepinephrine.Ziprasidone exhibits high affinity for human 5-HT receptors and human dopamine D(2) receptors. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 1 mg/mL, Sonication is recommended.
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| Keywords | Ziprasidone hydrochloride | CP88059 | Inhibitor | Dopamine Receptor | serotonin | CP-88059 | CP 88059 hydrochloride | Ziprasidone hydrochloride monohydrate | Ziprasidone Hydrochloride | Serotonin Receptor | Ziprasidone hydrochloride Monohydrate | 5-hydroxytryptamine Receptor | HEK-293 | antipsychotic agent | inhibit | 5-HT Receptor |
| Inhibitors Related | Alverine citrate | Dapoxetine hydrochloride | Meclizine dihydrochloride | Lidocaine | Famotidine | Octopamine hydrochloride | Oxolinic acid | Alginic acid | Trazodone hydrochloride |
| Related Compound Libraries | Pain-Related Compound Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Drug Repurposing Compound Library | Inhibitor Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Drug Library |
United States
