| Common Name | Ziprasidone Hydrochloride Monohydrate |
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| CAS Number | 138982-67-9 | Molecular Weight | 467.412 |
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| Density | N/A | Boiling Point | 554.8ºC at 760 mmHg |
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| Molecular Formula | C21H24Cl2N4O2S | Melting Point | 300°C |
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| MSDS | ChineseUSA | Flash Point | N/A |
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| Symbol |  
GHS07, GHS08 | Signal Word | Warning |
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Use of Ziprasidone Hydrochloride Monohydrate
Ziprasidone(CP88059) is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects of antipsychotic activity.Target: 5-HT receptor; Dopamine receptorZiprasidone (hydrochloride) is the salt form of ziprasidone, which possesses an in vitro 5-HT2A/dopamine D2 receptor affinity ratio higher than any clinically available antipsychotic agent. In vivo, ziprasidone antagonizes 5-HT2A receptor-induced head twitch with 6-fold higher potency than for blockade of d-amphetamine-induced hyperactivity, a measure of central dopamine D2 receptor antagonism. Ziprasidone also has high affinity for the 5-HT1A, 5-HT1D and 5-HT2C receptor subtypes, which may further enhance its therapeutic potential [1]. Ziprasidone sulfoxide and sulfone were the major metabolites in human serum. The affinities of the sulfoxide and sulfone metabolites for 5-HT2 and D2 receptors are low with respect to ziprasidone, and are thus unlikely to contribute to its antipsychotic effects [2]. Ziprasidone was associated with significant differential adverse effects relative to placebo in BPM, BPD, and schizophrenia with no significant difference in weight gain in all 3 groups. Self-reported somnolence was increased across the 3 conditions. Subjects with BPM were more vulnerable to EPS than those with BPD or schizophrenia [3].Clinical indications: Bipolar I disorder; Bipolar disorder; Mania; SchizophreniaFDA Approved Date: February 2001
| Boiling Point | 554.8ºC at 760 mmHg |
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| Melting Point | 300°C |
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| Molecular Formula | C21H24Cl2N4O2S |
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| Molecular Weight | 467.412 |
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| Exact Mass | 466.099701 |
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| PSA | 85.94000 |
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| LogP | 4.68760 |
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| Vapour Pressure | 2.38E-12mmHg at 25°C |
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| Storage condition | Room temp |
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