| CAS: | 20554-84-1 |
| MF: | C15H20O3 |
| MW: | 248.32 |
| EINECS: | 692-532-0 |
| Product Categories: | inhibitor;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Sesqui-Terpenoids;Isoprenoid/terpenoidNeurotransmitters;Anti-Proliferative AgentsNutrition Research;Antitumor Agents;Biochemicals Found in Plants;Cancer Research;Others;Natural Product;Serotonergics;Prostanoid receptor and related |
| Mol File: | 20554-84-1.mol |
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| Parthenolide Chemical Properties |
| Melting point | 115-116 °C (lit.) |
| alpha | D20 -81.4° (c = 1.04 in chloroform); D22 -71.4° (c = 0.220 in CH2Cl2) |
| Boiling point | 394.1±42.0 °C(Predicted) |
| density | 1.13±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 20 mg/ml) |
| form | White solid |
| color | White |
| Merck | 14,7048 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| InChI | InChI=1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5+/t11-,12-,13+,15+/m0/s1 |
| InChIKey | KTEXNACQROZXEV-PVLRGYAZSA-N |
| SMILES | O1C(=O)C(=C)[C@]2([H])CCC(C)=CCC[C@@]3(C)O[C@]3([H])[C@@]12[H] |t:10| |
| LogP | 2.424 (est) |
| CAS DataBase Reference | 20554-84-1 |
| Parthenolide Usage And Synthesis |
| Description | Parthenolide is an allergen in feverfew (Tanacetum parthenarium). |
| Chemical Properties | White solid |
| Uses | Antiinflammatory;MAP kinase inhibitor |
| Uses | Parthenolide is a sesquiterpene lactone from the plant feverfew (T. parthenium). It inhibits the growth of the promastigote form of L. amazonensis (IC50 = 3.6 μg/ml). Parthenolide also induces apoptosis in cancer cells, at least in part by inhibiting NF-κB- and STAT-mediated anti-apoptotic gene transcription. This compound has also been shown to block inflammation by inhibiting signaling through NF-κB. Inhibition of NF-κB by parthenolide can be achieved by direct binding of the pattern recognition receptor NOD2 by parthenolide. |
| Uses | Parthenolide is an anti-inflammatory agent used in the treatment of ischemic injury. Also acts as an anti-tumor and anti0leukemia agent targetting acute myeloid leukemia. |
| Definition | ChEBI: A sesquiterpene lactone and active principle of Feverfew (Tanacetum parthenium). |
| General Description | This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG |
Packing &shipping&Payment
Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Company information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.
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In stock
Japan
