| CAS: | 51-41-2 |
| MF: | C8H11NO3 |
| MW: | 169.18 |
| EINECS: | 200-096-6 |
| Product Categories: | chiral |
| Mol File: | 51-41-2.mol |
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| Norepinephrine Chemical Properties |
| Melting point | 220-230°C |
| alpha | D25 -37.3° (c = 5 in water with 1 equiv HCl) |
| Boiling point | 298.46°C (rough estimate) |
| density | 1.2435 (rough estimate) |
| refractive index | 1.5100 (estimate) |
| storage temp. | 2-8°C |
| solubility | Aqueous Acid (Slightly), DMSO (Slightly) |
| form | crystalline |
| pka | 8.64(at 25℃) |
| color | off-white to tan |
| Water Solubility | Soluble in alkali and dilute hydrochloric acid. Slightly soluble in water, ethanol and diethyl ether. |
| Sensitive | Air & Light Sensitive |
| Merck | 14,6695 |
| BRN | 4231961 |
| Stability: | Stable, but may be light-sensitive. Incompatible with acids, bases, oxidizing agents. Store at -20℃. |
| CAS DataBase Reference | 51-41-2(CAS DataBase Reference) |
| EPA Substance Registry System | Norepinephrine (51-41-2) |
| Norepinephrine Usage And Synthesis |
| Chemical Properties | solid |
| Uses | Vascular active drug resistance to shock |
| Uses | An adrenergic neurotransmitter. |
| Uses | Norepinephrine is used for increasing cardiac constriction and for the necessary elevation of blood pressure after sharp decline, which can result from surgical intervention or trauma. |
| Definition | ChEBI: The R-enantiomer of noradrenaline. |
| Brand name | Levophed (Hospira);Noradrec;Xylotox. |
| World Health Organization (WHO) | Vasoconstrictor agents have been in use for many years to prolong duration of action of local anaesthetics, particularly in dentistry. Combination products containing epinephrine or levarterenol in concentrations of 1:80,000 or less remain widely available. See also WHO comment for epinephrine. |
| Biological Functions | Most central noradrenergic neurons are located in the nucleus locus ceruleus of the pons and in neurons of the reticular formation. Fibers from these nuclei innervate a large number of cortical, subcortical, and spinomedullary fields. Many functions have been ascribed to the central noradrenergic neurons, including a role in affective disorders (see Chapter 33), in learning and memory, and in sleep–wake cycle regulation.The mammalian CNS contains both α- and β-adrenoceptors. |
| General Description | Norepinephrine (NE, Levophed) differs from DA onlyby addition of a 1-OH substituent (β-OH-DA) and from Eonly by lacking the N-methyl group. Like DA, it is polar andrapidly metabolized by both COMT and MAO, resulting inpoor oral bioavailability and short DOA (1 or 2 minutes evenwhen given intravenously). It is a stimulant of α1-, α2-, andβ1-adrenoceptors (notice that lacking the N-methyl group resultsin lacking β2- and β3-activity). It is used to counteractvarious hypotensive crises, because its α-activity raisesblood pressure and as an adjunct treatment in cardiac arrestbecause its β-activity stimulates the heart. It has limitedclinical application caused by the nonselective nature of itsactivities. |
| Hazard | May cause local tissue necrosis, headache, bradycardia, hypertension; poison; teratogen; mutagen. |
Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Company information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.
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