| Name | Norepinephrine |
| Description | Norepinephrine (Levophed) can stimulate apoptosis in adult rat ventricular myocytes by activation of the β-adrenergic pathway. It can up-regulate the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumour cells. |
| In vitro | METHODS: Adult hippocampal cells were treated with Norepinephrine (0.1-10 µM) for 10-13 days and the number of neurospheres was determined using classical neurosphere assay.
RESULTS: A significant increase in the number of neurospheres was obtained at 100 nm and in the presence of 1 µM Norepinephrine, and a twofold increase in the number of neurospheres was observed in the presence of 10 µM Norepinephrine. [1]
METHODS: Human pancreatic cancer cells BxPC-3 and Panc-1 were treated with Norepinephrine (10 µM) for 12-48 h. Cell viability was assayed by MTT Assay.
RESULTS: Norepinephrine treatment alone significantly enhanced the viability of PDAC cells. [2] |
| In vivo | METHODS: To test in vivo activity, Norepinephrine (0.2-2 mg/kga) was administered intraperitoneally to C57BL6/J mice fed a high-fat diet once daily for two weeks.
RESULTS: A subset of Norepinephrine-treated mice developed unexpected adverse events, including bladder dilatation and decreased renal perfusion due to renal discoloration. [3] |
| Storage | keep away from direct sunlight,keep away from moisture,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : < 1 mg/mL (Insoluble)
DMSO : 6.25 mg/mL (36.94 mM), Sonification is recommended.
10% DMSO+90% Saline : 0.1 mg/mL (0.59 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.
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| Keywords | Autophagy | Beta Receptor | inhibit | Levarterenol | Inhibitor | Norepinephrine | Endogenous Metabolite | Adrenergic Receptor |
| Inhibitors Related | Sucrose | Hydroxychloroquine | Daidzein | Guanidine hydrochloride | Doxycycline | Ferulic Acid | Paeonol | Glycerol | Thymidine |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Alkaloid Natural Product Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Human Endogenous Metabolite Library | Anti-Aging Compound Library | GPCR Compound Library | Food as Medicine Compound Library |
United States
