| CAS: | 480-19-3 |
| MF: | C16H12O7 |
| MW: | 316.26 |
| EINECS: | 207-545-5 |
| Melting point | 307°C |
| Boiling point | 599.4±50.0 °C(Predicted) |
| density | 1.634±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMF: 10 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml |
| form | Solid |
| pka | 6.31±0.40(Predicted) |
| color | Light yellow to Amber to Dark green |
1. Isorhamnetin is a flavonoid, which occurs naturally in plants and it is also a metabolite of quercetin.
Isorhamnetin has anti-inflammatory effect as it can reduce the formation of large amounts of nitric oxide by the inhibition the activation of nuclear factor-κB (NF-κB), which is a significant transcription factor for inducible nitric oxide synthase. Isorhamnetin is also reported to have effect in inducing the expression of neurofilaments, and it potentiated the NGF-induced neurite outgrowth and neurofilament expression, which could be a new direction in searching potential candidates as new drugs or food supplements for neurodegenerative diseases.
2. Isorhamnetin is a natural flavonol aglycone that is the 3-methyl metabolite of quercetin . It has antioxidant activity and inhibits xanthine oxidase (IC50 = 0.40 μM). Isorhamnetin also competitively inhibits the human multidrug and toxic compounds extrusion transporter 1 (Ki = 0.32 μM), which has an important role in the excretion of xenobiotics at the kidney and liver. It has also been reported to potentiate the neurological actions of nerve growth factor, diminish the cardiotoxic impact of doxorubicin, and have beneficial anti-cancer effects.
3. Isorhamnetin is a metabolite of the flavanoid Quercetin with antioxidant properties. It helps to protect H9c2 cardiomyoblasts against H2O2-induced oxidative stress via the modulation of PI3K/Akt and ERK1/2 signaling pathways.
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